Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137870 | 0.90 | NR4A2 (0.40) | POLBPARP1NR4A2ALOX5GAA | |
| SCHEMBL6137831 | 0.81 | ABL1 (0.46) | POLBALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL30582332 | 0.81 | ABL1 (0.46) | POLBALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL6137727 | 0.81 | NQO2 (0.34) | POLBALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL21986865 | 0.74 | LMNA (0.40) | POLBPARP1ALDH1A1MEN1HPGD | |
| SCHEMBL1081543 | 0.73 | LMNA (0.39) | POLBPARP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL1080724 | 0.73 | QPCT (0.44) | POLBPARP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL24754415 | 0.73 | SMN1; SMN2 (0.39) | PARP1KDM4EMEN1KMT2AACLY | |
| SCHEMBL6137705 | 0.72 | DPP4 (0.48) | POLBPARP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL1081831 | 0.71 | ALDH1A1 (0.40) | POLBPARP1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515956-A4 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-1515956-A1 | PEPTIDE DEFORMYLASE INHIBITORS | Smithkline Beecham (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003104209-A1 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-12-18 | — | — | WO | disclosed |