Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137843 | 0.79 | TDP1 (0.45) | MAPTLMNATDP1SMN1; SMN2NPC1 | |
| SCHEMBL1744969 | 0.74 | NOS1 (0.52) | TDP1SMN1; SMN2NPC1RAB9AOPRK1 | |
| SCHEMBL6137934 | 0.74 | SCN5A (0.49) | MAPTSCN5ASCN2AL3MBTL1NPC1 | |
| SCHEMBL6137825 | 0.74 | HPGD (0.50) | SCN5ASCN2AL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6137874 | 0.73 | F2 (0.54) | SCN5ASCN2AL3MBTL1ALDH1A1GPR52 | |
| Hydrochloric Acid SCHEMBL7873820 | 0.72 | AR (0.51) | MAPTALDH1A1HPGDKDM4E | |
| SCHEMBL25416131 | 0.71 | ALOX5 (0.51) | MAPTLMNATDP1SMN1; SMN2NPC1 | |
| SCHEMBL6003647 | 0.71 | LPAR1 (0.53) | MAPTTDP1SCN5ASCN2AL3MBTL1 | |
| SCHEMBL14802220 | 0.70 | ALDH1A1 (0.70) | MAPTLMNATDP1TP53CCR6 | |
| SCHEMBL11213620 | 0.70 | CES2 (0.47) | MAPTTDP1L3MBTL1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032556-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE INC (US) | 2005-02-02 | — | — | EP | claimed |
| EP-1032556-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-09-06 | — | — | EP | claimed |
| WO-1999020599-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-04-29 | — | — | WO | claimed |