Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 5/20 | 0.34 |
| ▸ | CASP7 | P55210 | 4/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | CASP9 | P55211 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767458 | 1.00 | HDAC8 (0.37) | HDAC8HDAC6HDAC1VEGFAEGLN1 | |
| SCHEMBL2769019 | 1.00 | HDAC8 (0.37) | HDAC8HDAC6HDAC1VEGFAEGLN1 | |
| SCHEMBL6137742 | 0.84 | VCAM1 (0.36) | HDAC8HDAC6HDAC1CASP3CASP7 | |
| SCHEMBL2768514 | 0.84 | VCAM1 (0.36) | HDAC8HDAC6HDAC1CASP3CASP7 | |
| SCHEMBL2768872 | 0.84 | VCAM1 (0.36) | HDAC8HDAC6HDAC1CASP3CASP7 | |
| SCHEMBL6563959 | 0.82 | CASP3 (0.45) | KCNH2CASP3CASP7CASP9 | |
| SCHEMBL6141269 | 0.80 | VEGFA (0.35) | HDAC8HDAC6HDAC1VEGFAEGLN1 | |
| SCHEMBL2768886 | 0.79 | ALDH1A1 (0.41) | VEGFAEGLN1CXCR2 | |
| SCHEMBL2769385 | 0.78 | CXCR2 (0.48) | CXCR2 | |
| SCHEMBL2768498 | 0.78 | CXCR2 (0.48) | CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261329-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1261329-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001068033-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |