Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.37 |
| ▸ | PPARG | P37231 | 6/20 | 0.37 |
| ▸ | PPARD | Q03181 | 6/20 | 0.37 |
| ▸ | PPARA | Q07869 | 6/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | FABP4 | P15090 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6138493 | 0.76 | OPRM1 (0.39) | OPRM1OPRL1LMNAKMT2A | |
| SCHEMBL2558530 | 0.71 | LMNA (0.46) | LMNASLC22A6TSHRNFKB1PMP22 | |
| Glutarate SCHEMBL5874406 | 0.69 | SLC22A6 (0.73) | LMNASLC22A6TSHRNFKB1PMP22 | |
| Adipic Acid SCHEMBL5874870 | 0.69 | LMNA (0.73) | LMNASLC22A6TSHRNFKB1PMP22 | |
| Adipic Acid SCHEMBL5874879 | 0.69 | LMNA (0.73) | LMNASLC22A6TSHRNFKB1PMP22 | |
| Glutarate SCHEMBL5874412 | 0.69 | SLC22A6 (0.73) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL14943788 | 0.68 | CAMK2A (0.42) | LMNASLC22A6TSHRNFKB1PMP22 | |
| SCHEMBL249726 | 0.67 | CAMK2A (0.46) | LMNASLC22A6TSHRNFKB1PMP22 | |
| Sebacic Acid SCHEMBL5874992 | 0.66 | TSHR (0.75) | LMNASLC22A6TSHRNFKB1PMP22 | |
| Trimethylammonium SCHEMBL11145139 | 0.66 | TSHR (0.75) | LMNASLC22A6TSHRNFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-B1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-12-21 | — | — | EP | claimed |