Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29215232 | 0.85 | KDM4E (0.39) | SMN1; SMN2KDM4EGAAALDH1A1CYP3A4 | |
| SCHEMBL30311415 | 0.85 | KDM4E (0.39) | SMN1; SMN2KDM4EGAAALDH1A1CYP3A4 | |
| SCHEMBL4915468 | 0.83 | TTR (0.35) | HTTTTRPPARGPPARA | |
| Bromide SCHEMBL4434122 | 0.81 | SIGMAR1 (0.38) | SMN1; SMN2POLBHTTTTRCA2 | |
| SCHEMBL13813240 | 0.81 | MAPT (0.35) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL13813243 | 0.80 | MAPT (0.34) | SMN1; SMN2POLBHTTTTRCA2 | |
| SCHEMBL31139295 | 0.80 | ABCB1 (0.40) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL4707752 | 0.79 | MAPT (0.43) | HTTCA2MAPTKDM4EGAA | |
| SCHEMBL499011 | 0.79 | DRD2 (0.50) | SMN1; SMN2POLBHTTNPC1RAB9A | |
| SCHEMBL30583955 | 0.78 | ENPP2 (0.36) | NPC1RAB9ACA2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547686-B2 | Combretastatin A-3 prodrug | Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on Behalf of the Arizona State University (US) | 2009-06-16 | — | — | US | disclosed |
| EP-1395265-A4 | COMBRETASTATIN A-3 PRODRUG | UNIV ARIZONA (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-1395265-A2 | COMBRETASTATIN A-3 PRODRUG | ARIZONA BOARD OF REGENTS (US) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002102766-A2 | COMBRETASTATIN A-3 PRODRUG | ARIZONA BOARD OF REGENTS (US) | 2002-12-27 | — | — | WO | disclosed |