Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | TACR1 | P25103 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6361803 | 0.92 | KDM4E (0.53) | KDM4EMAPK1KMT2AMEN1ALDH1A1 | |
| Fumaric Acid SCHEMBL6361804 | 0.92 | KDM4E (0.53) | KDM4EMAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2162623 | 0.86 | MEN1 (0.63) | KDM4EMAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL6139376 | 0.84 | LMNA (0.55) | KDM4EMAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7923519 | 0.84 | LMNA (0.61) | KDM4EMAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7924162 | 0.84 | KDM4E (0.62) | KDM4EKMT2AALDH1A1DRD2DRD4 | |
| SCHEMBL7921522 | 0.82 | KMT2A (0.56) | KDM4EKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL7927315 | 0.82 | KDM4E (0.58) | KDM4EALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL7927267 | 0.81 | MAPT (0.49) | KDM4EMAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7924133 | 0.81 | LMNA (0.48) | KDM4EMAPK1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130982-A1 | Oral therapeutic or preventative drugs for pollakiuria and urinary incontinence and oral sleep inducers, containing tropolone derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2005-06-16 | — | — | US | claimed |
| EP-1504759-A1 | ORAL THERAPEUTIC OR PREVENTIVE DRUGS FOR POLLAKIURIA AND URINARY INCONTINENCE OR ORAL SLEEP INDUCERS, CONTAINING TROPOLONE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2005-02-09 | — | — | EP | claimed |
| US-20050130982-A1 | Oral therapeutic or preventative drugs for pollakiuria and urinary incontinence and oral sleep inducers, containing tropolone derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2005-06-16 | — | — | US | disclosed |
| EP-1504759-A1 | ORAL THERAPEUTIC OR PREVENTIVE DRUGS FOR POLLAKIURIA AND URINARY INCONTINENCE OR ORAL SLEEP INDUCERS, CONTAINING TROPOLONE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2005-02-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130982-A1 | Oral therapeutic or preventative drugs for pollakiuria and urinary incontinence and oral sleep inducers, containing tropolone derivatives | MTNR1A, SULT2A1, MTNR1B | KDM4E 2173/4885MAPK1 2836/4885KMT2A 1033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.