Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28474124 | 0.82 | MEN1 (0.74) | MAPTMEN1KMT2ACA1CA2 | |
| SCHEMBL6139623 | 0.82 | MAPT (0.69) | MAPTMEN1KMT2ACES2CES1 | |
| SCHEMBL9210472 | 0.80 | MAPT (0.67) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL6218138 | 0.80 | MAPT (0.67) | MAPTMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL9619495 | 0.79 | MAPT (0.66) | MAPTMEN1KMT2ACES2CES1 | |
| SCHEMBL5931364 | 0.79 | MEN1 (1.00) | MAPTMEN1KMT2ATNFRSF1AALDH1A1 | |
| SCHEMBL19024320 | 0.79 | MAPT (0.66) | MAPTCYP1A2CYP2C19TNFRSF1ACES2 | |
| SCHEMBL6215505 | 0.78 | MAPT (0.64) | MAPTMEN1KMT2ACES2CES1 | |
| SCHEMBL6139674 | 0.78 | MAPT (0.63) | MAPTMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL6139673 | 0.78 | MAPT (0.63) | MAPTMEN1KMT2ACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458717-B1 | AROYL PYRIDINONES | BAYER HEALTHCARE AG (DE) | 2005-09-07 | — | — | EP | disclosed |
| US-20050070555-A1 | Aroyl pyridinones | BAYER HEALTHCARE AG | 2005-03-31 | — | — | US | disclosed |
| US-6844337-B2 | 1,4-diazabicyclo[3.2.2]nonane-phenylisoxazole derivatives, their preparation and their application in therapeutics | SANOFI-SYNTHELABO (FR) | 2005-01-18 | — | — | US | disclosed |
| EP-1458717-A1 | AROYL PYRIDINONES | Bayer HealthCare AG (DE) | 2004-09-22 | — | — | EP | disclosed |
| EP-1289986-B1 | 1,4-DIAZABICYCLO 3.2.2]NONANE-PHENYLISOXAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SYNTHELABO (FR) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003053967-A1 | AROYL PYRIDINONES | BAYER HEALTHCARE AG (DE) | 2003-07-03 | — | — | WO | disclosed |
| US-20030114461-A1 | 1,4-Diazabicyclo[3.2.2]nonane-phenylisoxazole derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2003-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114461-A1 | 1,4-Diazabicyclo[3.2.2]nonane-phenylisoxazole derivatives, preparation and therapeutic use thereof | CYC1, GLRA1, CBR1 | MAPT 4765/4885MEN1 1537/4885KMT2A 3489/4885 |
| US-20050070555-A1 | Aroyl pyridinones | PNPO, NDUFV2, NDUFS6 | MAPT 3342/4885MEN1 4688/4885KMT2A 3958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.