Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6140423 | 0.98 | HIF1A (0.40) | HIF1AHDAC4GAAKCNQ2HDAC3 | |
| SCHEMBL6140774 | 0.83 | KMT2A (0.43) | GAAF10USP2ESR1MAPT | |
| SCHEMBL6139850 | 0.78 | HIF1A (0.38) | HIF1AHDAC4GAAKCNQ2HDAC3 | |
| SCHEMBL6139855 | 0.78 | HIF1A (0.38) | HIF1AHDAC4GAAKCNQ2HDAC3 | |
| SCHEMBL17968495 | 0.73 | GAA (0.58) | HDAC4GAAHDAC3HDAC7HDAC8 | |
| SCHEMBL7166322 | 0.73 | CYP2C9 (0.53) | F10USP2ESR1MAPTNR4A1 | |
| SCHEMBL5631637 | 0.70 | CYP1A2 (0.41) | GAAF10USP2ESR1MAPT | |
| SCHEMBL5630404 | 0.70 | F10 (0.41) | F10MAPTNPSR1 | |
| SCHEMBL28177937 | 0.69 | SIGMAR1 (0.54) | KMT2A | |
| SCHEMBL6139947 | 0.68 | RAB9A (0.54) | MAPTNR4A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499591-A1 | CARBOXYLIC ACID AMIDES | MERCK PATENT GmbH (DE) | 2005-01-26 | — | — | EP | claimed |
| WO-2003093235-A1 | CARBOXYLIC ACID AMIDES | MERCK PATENT GMBH (DE) | 2003-11-13 | — | — | WO | claimed |