Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467859 | 0.93 | LMNA (0.45) | P2RY12HRH3LMNADGAT1ALDH1A1 | |
| SCHEMBL5243498 | 0.84 | LMNA (0.48) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6139555 | 0.82 | LMNA (0.42) | LMNADGAT1ALDH1A1MAPTMEN1 | |
| SCHEMBL7560376 | 0.81 | LMNA (0.56) | P2RY12HRH3LMNADGAT1ALDH1A1 | |
| SCHEMBL7472518 | 0.81 | LMNA (0.45) | P2RY12HRH3LMNADGAT1ALDH1A1 | |
| SCHEMBL7470650 | 0.81 | LMNA (0.46) | P2RY12HRH3LMNADGAT1ALDH1A1 | |
| SCHEMBL6140070 | 0.81 | ALDH1A1 (0.47) | LMNAUSP30NPC1ALDH1A1MAPT | |
| SCHEMBL7461831 | 0.81 | LMNA (0.46) | P2RY12HRH3LMNADGAT1ALDH1A1 | |
| SCHEMBL7458989 | 0.81 | HRH3 (0.43) | P2RY12HRH3LMNAUSP30OGA | |
| SCHEMBL6139717 | 0.76 | HSD17B10 (0.40) | HRH3USP30ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852736-B2 | Phenoxypropanolamines, preparation and therapeutic use thereof | SANOFI-SYNTHELABO (FR) | 2005-02-08 | — | — | US | disclosed |
| US-20030105135-A1 | Phenoxypropanolamines, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2003-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105135-A1 | Phenoxypropanolamines, preparation and therapeutic use thereof | CNR1, ADRB3, ADRB1 | P2RY12 1651/4885SGPL1 1217/4885HRH3 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.