Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823580 | 0.86 | MAPT (0.36) | MAPTPKMVCPMAPK1ATM | |
| SCHEMBL17219535 | 0.86 | MAPT (0.36) | MAPTPKMVCPMAPK1ATM | |
| SCHEMBL1994831 | 0.84 | TDP1 (0.41) | ATMTDP1ALDH1A1TSHRHIF1A | |
| SCHEMBL1149199 | 0.83 | MAPT (0.37) | MAPTPKMVCPMAPK1ATM | |
| SCHEMBL23580766 | 0.83 | MAPT (0.37) | MAPTPKMVCPMAPK1ATM | |
| SCHEMBL2897221 | 0.82 | GPR35 (0.41) | MAPTPKMVCPMAPK1TDP1 | |
| SCHEMBL18298070 | 0.82 | MAPT (0.34) | MAPTPKMVCPMAPK1ATM | |
| SCHEMBL17219091 | 0.82 | TSHR (0.44) | MAPTPKMVCPMAPK1ATM | |
| SCHEMBL18614418 | 0.82 | GRIN2D (0.39) | MAPTPKMVCPMAPK1TDP1 | |
| SCHEMBL26921407 | 0.82 | GRIN2D (0.47) | MAPTPKMVCPMAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525183-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-04-27 | — | — | EP | disclosed |
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | disclosed |
| WO-2004002940-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142993-A1 | Inhibitors of HCV NS5B polymerase | POLRMT, POLR1E, CTDSP1 | MAPT 3583/4885PKM 4388/4885VCP 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.