Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 6/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.58 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 2/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23484536 | 0.84 | KDM4E (0.67) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL26672809 | 0.83 | ADRA2A (0.70) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL11743203 | 0.77 | KDM4E (0.57) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL28196898 | 0.76 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL28196899 | 0.76 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL5492653 | 0.76 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL6145383 | 0.75 | ADRA2A (0.63) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL17049583 | 0.72 | KDM4E (0.51) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL6320542 | 0.72 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| L-Adrenaline SCHEMBL11647 | 0.70 | KDM4E (1.00) | ADRA2AADRA2BADRA2CADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487784-A4 | NOVEL TRIFLUOROMETHYLEPINEPHRINE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | US ARMY MED RES MAT COMMAND (US) | 2005-03-30 | — | — | EP | claimed |
| EP-1487784-A2 | NOVEL TRIFLUOROMETHYLEPINEPHRINE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | U.S. Army Medical Research and Materiel Command (US) | 2004-12-22 | — | — | EP | claimed |
| US-6825382-B2 | VASOCONSTRICTORS THAT ARE USED TO PROLONG THE ACTIVITY OF LOCAL ANESTHETICS IN DENTAL PREPARATIONS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2004-11-30 | — | — | US | claimed |
| US-20040015015-A1 | Novel trifluoromethylepinephrine compounds and methods of making and using thereof | UNITED STATES ARMY | 2004-01-22 | — | — | US | claimed |
| WO-2003103609-A2 | NOVEL TRIFLUOROMETHYLEPINEPHRINE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (US) | 2003-12-18 | — | — | WO | claimed |
| EP-1487784-A4 | NOVEL TRIFLUOROMETHYLEPINEPHRINE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | US ARMY MED RES MAT COMMAND (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1487784-A2 | NOVEL TRIFLUOROMETHYLEPINEPHRINE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | U.S. Army Medical Research and Materiel Command (US) | 2004-12-22 | — | — | EP | disclosed |
| US-6825382-B2 | VASOCONSTRICTORS THAT ARE USED TO PROLONG THE ACTIVITY OF LOCAL ANESTHETICS IN DENTAL PREPARATIONS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2004-11-30 | — | — | US | disclosed |
| US-20040015015-A1 | Novel trifluoromethylepinephrine compounds and methods of making and using thereof | UNITED STATES ARMY | 2004-01-22 | — | — | US | disclosed |
| WO-2003103609-A2 | NOVEL TRIFLUOROMETHYLEPINEPHRINE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (US) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040015015-A1 | Novel trifluoromethylepinephrine compounds and methods of making and using thereof | NPY5R, NPY1R, HTR5A | ADRA2A 64/4885ADRA2B 58/4885ADRA2C 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.