Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.63 |
| ▸ | TTR | P02766 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | AR | P10275 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9472492 | 0.92 | ACHE (0.63) | ACHETTRL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL13799708 | 0.90 | TTR (0.47) | ACHETTRL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL17258622 | 0.88 | ACHE (0.68) | ACHETTRL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL11784875 | 0.82 | CA12 (0.65) | TTRL3MBTL1ALDH1A1MAPK1HTT | |
| SCHEMBL9923550 | 0.81 | L3MBTL1 (0.49) | ACHETTRL3MBTL1ALDH1A1MAPT | |
| SCHEMBL16118592 | 0.80 | MAPT (0.53) | TTRL3MBTL1ALDH1A1ARMAPT | |
| SCHEMBL822665 | 0.80 | TSHR (0.50) | ACHEALDH1A1HTTHPGDCYP2C9 | |
| SCHEMBL8484975 | 0.80 | NTRK1 (0.48) | ALDH1A1HTTHPGDNTRK1IGF1R | |
| SCHEMBL30695769 | 0.80 | TSHR (0.50) | ACHEALDH1A1HTTHPGDCYP2C9 | |
| SCHEMBL12770846 | 0.80 | ALDH1A1 (0.55) | ACHETTRL3MBTL1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020141439-A1 | HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2020-07-09 | — | — | WO | disclosed |
| US-9802920-B2 | Inhibitors of bruton's tyrosine kinase | HOFFMAN-LA ROCHE INC. (US) | 2017-10-31 | — | — | US | disclosed |
| US-9624239-B2 | Protein kinase inhibitors | PHARMASCIENCE INC. (CA) | 2017-04-18 | — | — | US | disclosed |
| US-20160304497-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | CHUGAI PHARMACEUTICAL CO. (JP) | 2016-10-20 | — | — | US | disclosed |
| US-9056862-B2 | Thioxothiazolidine derivative having Ras function inhibitory effect | NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (JP) | 2015-06-16 | — | — | US | disclosed |
| US-9056862-B2 | Thioxothiazolidine derivative having Ras function inhibitory effect | NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY (JP) | 2015-06-16 | — | — | US | disclosed |
| US-20140194412-A1 | THIOXOTHIAZOLIDINE DERIVATIVE HAVING RAS FUNCTION INHIBITORY EFFECT | KNC LABORATORIES CO., LTD. (JP) | 2014-07-10 | — | — | US | disclosed |
| US-20140194412-A1 | THIOXOTHIAZOLIDINE DERIVATIVE HAVING RAS FUNCTION INHIBITORY EFFECT | KNC LABORATORIES CO., LTD. (JP) | 2014-07-10 | — | — | US | disclosed |
| US-20140045833-A1 | Protein Kinase Inhibitors | PHARMASCIENCE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| EP-0727141-B1 | Fungicidal methods, compounds and compositions containing benzophenones | BASF AG (DE) | 2005-11-02 | — | — | EP | disclosed |
| US-5922919-A | Fungicidal methods, compounds and compositions containing benzophenones | AMERICAN CYANAMID COMPANY (US) | 1999-07-13 | — | — | US | disclosed |
| US-5866722-A | Fungicidal methods compounds and compositions containing benzophenones | AMERICAN CYANAMID COMPANY (US) | 1999-02-02 | — | — | US | disclosed |
| US-5773663-A | FOR CONTROL OF PHYTOPATHOGENIC FUNGI IN CROPS | AMERICAN CYANAMID COMPANY (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0727141-A2 | Fungicidal methods, compounds and compositions containing benzophenones | American Cyanamid Company (US) | 1996-08-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045833-A1 | Protein Kinase Inhibitors | LCK, BTK, TEC | ACHE 4350/4885TTR 2965/4885L3MBTL1 3406/4885 |
| US-20140194412-A1 | THIOXOTHIAZOLIDINE DERIVATIVE HAVING RAS FUNCTION INHIBITORY EFFECT | KRAS, NRAS, RASSF5 | ACHE 4090/4885TTR 2830/4885L3MBTL1 3403/4885 |
| US-20160304497-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, SYK, LYN | ACHE 2600/4885TTR 4320/4885L3MBTL1 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.