Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243856 | 1.00 | ABCG2 (0.47) | ABCG2ALDH1A1TSHRAKR1C3MEN1 | |
| SCHEMBL11877949 | 0.82 | AKR1C3 (0.52) | ABCG2ALDH1A1TSHRAKR1C3MEN1 | |
| SCHEMBL6262041 | 0.81 | AKR1C3 (0.55) | ABCG2ALDH1A1TSHRAKR1C3MEN1 | |
| SCHEMBL9103420 | 0.81 | ABCG2 (0.54) | ABCG2ALDH1A1TSHRAKR1C3MEN1 | |
| SCHEMBL3818255 | 0.81 | AKR1C3 (0.55) | ABCG2ALDH1A1TSHRAKR1C3MEN1 | |
| SCHEMBL3485765 | 0.81 | AKR1C3 (0.55) | ABCG2ALDH1A1TSHRAKR1C3MEN1 | |
| SCHEMBL83065 | 0.81 | AKR1C3 (0.55) | ABCG2ALDH1A1TSHRAKR1C3MEN1 | |
| SCHEMBL5047540 | 0.79 | RECQL (0.55) | ABCG2ALDH1A1TSHRAKR1C3MEN1 | |
| SCHEMBL8351839 | 0.79 | AKR1C3 (0.53) | ABCG2ALDH1A1TSHRAKR1C3MEN1 | |
| Hydrochloric Acid SCHEMBL10437231 | 0.79 | AKR1C3 (0.53) | ABCG2ALDH1A1TSHRAKR1C3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656510-B2 | Antidepressants | INDENA S.P.A. (IT) | 2003-12-02 | — | — | US | claimed |
| US-20010020040-A1 | Hyperforin derivatives, use thereof and formulations containing them | INDENA S.P.A. (IT) | 2001-09-06 | — | — | US | claimed |
| EP-1086071-A1 | HYPERFORIN DERIVATIVES, THE USE THEREOF AND FORMULATIONS CONTAINING THEM | INDENA S.p.A. (IT) | 2001-03-28 | — | — | EP | claimed |
| WO-1999064388-A1 | HYPERFORIN DERIVATIVES, THE USE THEREOF AND FORMULATIONS CONTAINING THEM | INDENA S.P.A. (IT) | 1999-12-16 | — | — | WO | claimed |
| JP-57032255-A | — | — | None | — | — | JP | disclosed |
| EP-1607099-A1 | Use of hyperforin derivatives as an antidepressant agent | INDENA S.p.A. (IT) | 2005-12-21 | — | — | EP | disclosed |
| US-6656510-B2 | Antidepressants | INDENA S.P.A. (IT) | 2003-12-02 | — | — | US | disclosed |
| US-20010020040-A1 | Hyperforin derivatives, use thereof and formulations containing them | INDENA S.P.A. (IT) | 2001-09-06 | — | — | US | disclosed |
| EP-1086071-A1 | HYPERFORIN DERIVATIVES, THE USE THEREOF AND FORMULATIONS CONTAINING THEM | INDENA S.p.A. (IT) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064388-A1 | HYPERFORIN DERIVATIVES, THE USE THEREOF AND FORMULATIONS CONTAINING THEM | INDENA S.P.A. (IT) | 1999-12-16 | — | — | WO | disclosed |
| JP-S5732255-A | TRIMETHOXYPHENYL DERIVATIVE | KOWA CO | 1982-02-20 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020040-A1 | Hyperforin derivatives, use thereof and formulations containing them | CRH, FOS, VIP | ABCG2 1183/4885ALDH1A1 2180/4885TSHR 3026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.