Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 3/20 | 0.39 |
| ▸ | BECN1 | Q14457 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30728980 | 0.84 | NAMPT (0.39) | PSMB8CYP17A1PRKDCBRD4CREBBP | |
| SCHEMBL20865536 | 0.79 | CYP17A1 (0.68) | PSMB8CYP17A1PRKDCBRD4CREBBP | |
| SCHEMBL13055402 | 0.77 | CYP17A1 (0.59) | PSMB8CYP17A1MAP4K4NAMPTCA12 | |
| SCHEMBL23728299 | 0.75 | PSMB8 (0.48) | PSMB8CYP17A1PRKDCBRD4CREBBP | |
| SCHEMBL30817405 | 0.74 | MAPT (0.50) | PSMB8PRKDCCD274NAMPTDRD2 | |
| SCHEMBL12995665 | 0.73 | PSMB8 (0.46) | PSMB8CYP17A1PRKDCBRD4CREBBP | |
| SCHEMBL29986622 | 0.73 | PRKDC (0.49) | PSMB8CYP17A1PRKDCCD274NAMPT | |
| SCHEMBL18570243 | 0.73 | CYP17A1 (0.61) | PSMB8CYP17A1CD274MAP4K4NAMPT | |
| SCHEMBL3968632 | 0.73 | CYP17A1 (0.61) | PSMB8CYP17A1PRKDCBRD4CD274 | |
| SCHEMBL615625 | 0.73 | PSMB8 (0.46) | PSMB8CYP17A1PRKDCBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612408-B2 | Pyrazolone-fused pyrimidine compound, preparation method for same and applications thereof | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2026-04-28 | — | — | US | disclosed |
| US-20220259210-A1 | Pyrazolone-Fused Pyrimidine Compound, Preparation Method for Same and Applications Thereof | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2022-08-18 | — | — | US | disclosed |
| EP-3992193-A1 | PYRAZOLOPYRIMIDINE COMPOUND, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF | Shanghai Pharmaceuticals Holding Co., Ltd. (CN) | 2022-05-04 | — | — | EP | disclosed |
| EP-3992193-A1 | PYRAZOLOPYRIMIDINE COMPOUND, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF | Shanghai Pharmaceuticals Holding Co., Ltd. (CN) | 2022-05-04 | — | — | EP | disclosed |
| WO-2020259703-A1 | PYRAZOLOPYRIMIDINE COMPOUND, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF | 上海医药集团股份有限公司 | 2020-12-30 | — | — | WO | disclosed |
| EP-2419419-B1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-03 | — | — | EP | disclosed |
| EP-2419419-B1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-03 | — | — | EP | disclosed |
| US-8513229-B2 | 4-Azetidinyl-1-phenyl-cyclohexane antagonists of CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2013-08-20 | — | — | US | disclosed |
| US-8513229-B2 | 4-Azetidinyl-1-phenyl-cyclohexane antagonists of CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2013-08-20 | — | — | US | disclosed |
| EP-2419419-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | Janssen Pharmaceutica, N.V. (BE) | 2012-02-22 | — | — | EP | disclosed |
| US-20120040960-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-02-16 | — | — | US | disclosed |
| US-20120040960-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-02-16 | — | — | US | disclosed |
| WO-2010121046-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010121046-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-21 | — | — | WO | disclosed |
| US-20100267689-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA N. V. (BE) | 2010-10-21 | — | — | US | disclosed |
| US-20100267689-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA N. V. (BE) | 2010-10-21 | — | — | US | disclosed |
| US-20100267689-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA N. V. (BE) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040960-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | CCR2, CCR1, CCR5 | PSMB8 3440/4885CYP17A1 508/4885PRKDC 4509/4885 |
| US-20220259210-A1 | Pyrazolone-Fused Pyrimidine Compound, Preparation Method for Same and Applications Thereof | WEE1, WEE2, PDXK | PSMB8 3458/4885CYP17A1 861/4885PRKDC 64/4885 |
| US-12612408-B2 | Pyrazolone-fused pyrimidine compound, preparation method for same and applications thereof | WEE1, WEE2, TK1 | PSMB8 3857/4885CYP17A1 144/4885PRKDC 177/4885 |
| US-20100267689-A1 | 4-AZETIDINYL-1-PHENYL-CYCLOHEXANE ANTAGONISTS OF CCR2 | CCR2, CCR1, CCR5 | PSMB8 3440/4885CYP17A1 508/4885PRKDC 4509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.