Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 9/20 | 0.49 |
| ▸ | SLC6A9 | P48067 | 8/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365015 | 1.00 | SLC18A3 (0.49) | SLC18A3SLC6A9CYP2D6SMN1; SMN2CYP1A2 | |
| SCHEMBL27646276 | 0.83 | SLC18A3 (0.46) | SLC18A3SLC6A9CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL27646273 | 0.83 | SLC18A3 (0.46) | SLC18A3SLC6A9CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL5372312 | 0.79 | KMT2A (0.44) | SLC18A3SLC6A9SMN1; SMN2OPRM1OPRL1 | |
| SCHEMBL22605778 | 0.77 | ALDH1A1 (0.45) | SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14141237 | 0.75 | MAPK3 (0.44) | SLC18A3CYP2D6SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL5379382 | 0.74 | SLC6A9 (0.48) | SLC18A3SLC6A9OPRM1SLC6A5 | |
| SCHEMBL5379386 | 0.74 | SLC6A9 (0.48) | SLC18A3SLC6A9OPRM1SLC6A5 | |
| SCHEMBL5742224 | 0.73 | NOS2 (0.47) | SLC18A3SLC6A9OPRM1OPRL1SLC6A5 | |
| SCHEMBL3951800 | 0.73 | KDM4E (0.49) | SLC18A3SMN1; SMN2TSHROPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100372838-C | Piperidine-benzenesulfonamide derivatives | HOFFMANN LA ROCHE (CH) | 2008-03-05 | — | — | CN | disclosed |
| CN-1751023-A | Piperidine-benzenesulfonamide derivatives | HOFFMANN LA ROCHE (CH) | 2006-03-22 | — | — | CN | disclosed |
| EP-1594840-A1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004072034-A1 | PIPERIDINE-BENZENESULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-26 | — | — | WO | disclosed |