Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | TTR | P02766 | 3/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.35 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.35 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943046 | 0.88 | PTGS2 (0.35) | PTGS2ADRA1ATTRABCB11CXCL8 | |
| SCHEMBL6938668 | 0.86 | PTGS2 (0.38) | PTGS2ADRA1ATTRABCB11CXCL8 | |
| SCHEMBL7241116 | 0.84 | KDM4E (0.41) | PTGS2ADRA1ATTRABCB11CXCL8 | |
| SCHEMBL6152944 | 0.83 | ADRA1A (0.36) | PTGS2ADRA1ATTRABCB11CXCL8 | |
| SCHEMBL6153142 | 0.80 | CYP2C9 (0.37) | PTGS2ADRA1ATTRABCB11CXCL8 | |
| SCHEMBL6941861 | 0.79 | PTGS2 (0.33) | PTGS2ADRA1AABCB11NR1H4PTGS1 | |
| SCHEMBL6152968 | 0.79 | SLC6A4 (0.35) | PTGS2ADRA1ATTRABCB11CXCL8 | |
| SCHEMBL7132448 | 0.78 | CXCL8 (0.34) | PTGS2ADRA1ATTRABCB11CXCL8 | |
| SCHEMBL6152414 | 0.76 | PTAFR (0.37) | ADRA1AABCB11KMT2ATBXA2RMEN1 | |
| SCHEMBL6945502 | 0.76 | HSD17B10 (0.36) | ADRA1AABCB11NR1H4KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | disclosed |