Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 7/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4590208 | 0.94 | SIGMAR1 (0.39) | HRH1HTR2ASLC6A4SLC7A5SIGMAR1 | |
| SCHEMBL27654798 | 0.92 | SLC7A5 (0.40) | HRH1HTR2ASLC6A4SLC7A5SIGMAR1 | |
| SCHEMBL3053696 | 0.87 | SLC6A4 (0.39) | HRH1HTR2ASLC6A4GSRCYP1A2 | |
| SCHEMBL28973810 | 0.79 | SLC7A5 (0.43) | HRH1HTR2ASLC6A4SLC7A5SLC6A2 | |
| SCHEMBL16872478 | 0.79 | HRH1 (0.38) | HRH1HTR2ASLC6A4SLC7A5TSHR | |
| SCHEMBL7453749 | 0.79 | POLB (0.44) | HRH1HTR2ASLC6A4SLC7A5SIGMAR1 | |
| SCHEMBL9174451 | 0.78 | HTR2A (0.39) | HRH1HTR2ASLC6A4GSRTSHR | |
| SCHEMBL904449 | 0.78 | HRH1 (0.60) | HRH1HTR2ASLC6A4SIGMAR1CYP1A2 | |
| SCHEMBL1459570 | 0.78 | SLC7A5 (0.44) | HTR2ASLC6A4SLC7A5SIGMAR1OPRM1 | |
| SCHEMBL8048483 | 0.76 | HTR2A (0.44) | HTR2ASLC7A5SIGMAR1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047938-B | 2,4, 6-trisubstituted pyrimidine compounds as ATR kinase inhibitors | 北京泰德制药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-113906026-A | 2,4, 6-trisubstituted pyrimidine compounds as ATR kinase inhibitors | 北京泰德制药股份有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-112047938-A | 2,4, 6-trisubstituted pyrimidine compounds as ATR kinase inhibitors | 北京泰德制药股份有限公司 | 2020-12-08 | — | — | CN | disclosed |
| US-20050165057-A1 | Novel piperidine derivative | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2005-07-28 | — | — | US | disclosed |
| EP-1500648-A1 | NOVEL PIPERIDINE DERIVATIVE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165057-A1 | Novel piperidine derivative | ACAT2, ACAT1, LCAT | HRH1 852/4885HTR2A 4574/4885SLC6A4 2191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.