Elisartan

Elisartan

SCHEMBL615371

CCCCc1nc(Cl)c(C(=O)OC(C)OC(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1.[K]

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.52
AGTR2 P50052 3/20 0.52
PPARG P37231 1/20 0.45
KCNH2 Q12809 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Elisartan SCHEMBL29595840 1.00 AGTR1 (0.52) AGTR1AGTR2PPARGKCNH2
Elisartan SCHEMBL489081 0.99 AGTR1 (0.53) AGTR1AGTR2PPARGKCNH2
Elisartan SCHEMBL489079 0.99 AGTR1 (0.53) AGTR1AGTR2PPARGKCNH2
Elisartan SCHEMBL1560942 0.99 AGTR1 (0.52) AGTR1AGTR2PPARGKCNH2
Elisartan SCHEMBL615370 0.99 AGTR1 (0.52) AGTR1AGTR2PPARGKCNH2
SCHEMBL12990879 0.93 AGTR2 (0.53) AGTR1AGTR2PPARG
SCHEMBL6130076 0.92 AGTR1 (0.48) AGTR1AGTR2
SCHEMBL4609266 0.92 AGTR1 (0.48) AGTR1AGTR2
SCHEMBL12991717 0.91 AGTR2 (0.51) AGTR1AGTR2
SCHEMBL13771416 0.90 AGTR1 (0.48) AGTR1AGTR2PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1389105-A4 METHOD OF TREATMENT MERCK & CO INC (US) 2005-08-17 EP claimed
EP-1389105-A1 METHOD OF TREATMENT Merck & Co., Inc. (US) 2004-02-18 EP claimed
US-20030073705-A1 Method of treatment SHAHINFAR SHAHNAZ (US) 2003-04-17 US claimed
WO-2002092081-A1 METHOD OF TREATMENT MERCK & CO., INC. (US) 2002-11-21 WO claimed
US-6300356-B1 ADMINISTERING TO A PATIENT IN NEED OF SUCH TREATMENT A THERAPEUTICALLY EFFECTIVE AMOUNT OF AN ANGIOTENSIN II RECEPTOR ANTAGONIST MERCK & CO., INC. 2001-10-09 US claimed
US-6201002-B1 ADMINISTERING IMIDAZOLE DERIVATIVE TO TREAT CONGESTIVE HEART FAILURE AND CARDIOVASCULAR DISORDERS MERCK & CO., INC. 2001-03-13 US claimed
EP-3241839-B1 AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL, INFLAMMATION, CANCER AND OTHER DISORDERS BAUSCH HEALTH IRELAND LTD (IE) 2019-09-04 EP disclosed
EP-3239170-B1 AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS SYNERGY PHARMACEUTICALS INC (US) 2019-03-20 EP disclosed
EP-3366698-A1 GUANYLATE CYCLASE C AGONISTS Synergy Pharmaceuticals Inc. (US) 2018-08-29 EP disclosed
US-9920095-B2 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders SYNERGY PHARMACEUTICALS, INC. (US) 2018-03-20 US disclosed
EP-2810951-B1 Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders SYNERGY PHARMACEUTICALS INC (US) 2017-03-15 EP disclosed
US-20160367623-A1 AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS SYNERGY PHARMACEUTICALS INC. 2016-12-22 US disclosed
US-20160243188-A1 AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS JPMORGAN CHASE BANK, N.A. 2016-08-25 US disclosed
EP-1635773-A2 COMBINATION THERAPY FOR THE TREATMENT OF HYPERTENSION Merck & Co., Inc. (a New Jersey corp.) (US) 2006-03-22 EP disclosed
EP-1389105-A4 METHOD OF TREATMENT MERCK & CO INC (US) 2005-08-17 EP disclosed
WO-2004110368-A2 COMBINATION THERAPY FOR THE TREATMENT OF HYPERTENSION MERCK & CO., INC. (US) 2004-12-23 WO disclosed
US-20040116510-A1 Antihypertensive agent and cholesterol absorption inhibitor combination therapy NICHTBERGER STEVEN A (US) 2004-06-17 US disclosed
EP-1389105-A1 METHOD OF TREATMENT Merck & Co., Inc. (US) 2004-02-18 EP disclosed
US-20030073705-A1 Method of treatment SHAHINFAR SHAHNAZ (US) 2003-04-17 US disclosed
WO-2002092081-A1 METHOD OF TREATMENT MERCK & CO., INC. (US) 2002-11-21 WO disclosed