Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 2/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10048729 | 0.82 | CYP2C9 (0.36) | ALDH1A1HPGDMCL1ERN1PRKDC | |
| SCHEMBL23726022 | 0.82 | ALDH1A1 (0.34) | ALDH1A1GAAHPGDSMN1; SMN2CCR4 | |
| SCHEMBL25272811 | 0.81 | ALDH1A1 (0.36) | ALDH1A1GAAHPGDSMN1; SMN2CCR4 | |
| SCHEMBL23724851 | 0.79 | CCR4 (0.39) | ALDH1A1GAAHPGDSMN1; SMN2CCR4 | |
| SCHEMBL616113 | 0.78 | MCL1 (0.31) | MCL1ERN1 | |
| SCHEMBL18725395 | 0.76 | ALDH1A1 (0.33) | ALDH1A1GAAHPGDSMN1; SMN2LMNA | |
| SCHEMBL30431426 | 0.76 | KDM4E (0.34) | ALDH1A1LMNA | |
| SCHEMBL18031330 | 0.76 | KDM4E (0.34) | ALDH1A1LMNA | |
| SCHEMBL18725432 | 0.74 | SQOR (0.36) | ALDH1A1GAAHPGDSMN1; SMN2CCR4 | |
| SCHEMBL6368869 | 0.72 | HPGD (0.37) | HPGDCCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466287-B2 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2013-06-18 | — | — | US | disclosed |
| US-20120041204-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2012-02-16 | — | — | US | disclosed |
| US-8067595-B2 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2011-11-29 | — | — | US | disclosed |
| CN-101193895-B | Method for producing tricyclic ketone | YAKULT HONSHA KK | 2011-06-01 | — | — | CN | disclosed |
| US-20090023927-A1 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2009-01-22 | — | — | US | disclosed |
| CN-101193895-A | Method for producing tricyclic ketone | YAKULT HONSHA KK (JP) | 2008-06-04 | — | — | CN | disclosed |
| EP-1900740-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | Kabushiki Kaisha Yakult Honsha (JP) | 2008-03-19 | — | — | EP | disclosed |
| EP-0758333-B1 | INTERMEDIATES IN PHARMACEUTICAL CAMPTOTHECIN PREPARATION | OSI PHARM INC (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-0646117-B1 | METHODS AND INTERMEDIATES FOR THE ASYMMETRIC SYNTHESIS OF CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | UNIV NORTH CAROLINA STATE (US) | 2001-07-25 | — | — | EP | disclosed |
| JP-2001055377-A | INTERMEDIATE FOR SYNTHESIZING RAW MATERIAL COMPOUND FOR CAMPTOTHECIN AND ITS ANALOGUE | NORTH CAROLINA STATE UNIV | 2001-02-27 | — | — | JP | disclosed |
| US-5258516-A | Optically pure D,E ring intermediates useful for the synthesis of camptothecin and camptothecin analogs | NC STATE UNIVERSITY (US) | 1993-11-02 | — | — | US | disclosed |
| EP-0565621-A1 | METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5254690-A | Alkoxymethylpyridine d-ring intermediates useful for the synthesis of camptpthecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-10-19 | — | — | US | disclosed |
| US-5247089-A | Method of making intermediates useful for the manufacture of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-09-21 | — | — | US | disclosed |
| US-5243050-A | Alkylpyridone DE ring intermediates useful for the manufacture of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-09-07 | — | — | US | disclosed |
| US-5212317-A | Methods and intermediates for the assymmetric synthesis of camptothecin and camptothecin analogs | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-05-18 | — | — | US | disclosed |
| US-5200524-A | Camptothecin intermediates and method of making same | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-04-06 | — | — | US | disclosed |
| US-5191082-A | Camptothecin intermediate and method of making camptothecin intermediates | NORTH CAROLINA STATE UNIVERSITY (US) | 1993-03-02 | — | — | US | disclosed |
| US-5162532-A | INTERMEDIATES AND METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1992-11-10 | — | — | US | disclosed |
| WO-1992011263-A1 | METHOD OF MAKING CAMPTOTHECIN AND CAMPTOTHECIN ANALOGS | NORTH CAROLINA STATE UNIVERSITY (US) | 1992-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041204-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | TKT, DCK, COASY | ALDH1A1 1539/4885GAA 1506/4885HPGD 946/4885 |
| US-20090023927-A1 | Process for producing tricyclic ketone | TKT, DCK, COASY | ALDH1A1 1539/4885GAA 1506/4885HPGD 946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.