Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL615179 | 0.81 | POLB (0.32) | ERN1 | |
| SCHEMBL613905 | 0.81 | ERN1 (0.31) | ERN1 | |
| SCHEMBL10048729 | 0.81 | CYP2C9 (0.36) | MCL1ERN1 | |
| SCHEMBL614736 | 0.80 | PRKDC (0.40) | ERN1 | |
| SCHEMBL2579726 | 0.80 | NFE2L2 (0.31) | ERN1 | |
| SCHEMBL615593 | 0.78 | ALDH1A1 (0.33) | MCL1ERN1 | |
| SCHEMBL615268 | 0.78 | PRKDC (0.31) | ERN1 | |
| SCHEMBL3176525 | 0.75 | SQOR (0.35) | — | |
| SCHEMBL614127 | 0.70 | PDE4A (0.31) | — | |
| SCHEMBL6762127 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1378505-B1 | METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS | YAKULT HONSHA KK (JP) | 2014-11-05 | — | — | EP | disclosed |
| US-8466287-B2 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2013-06-18 | — | — | US | disclosed |
| US-8466287-B2 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2013-06-18 | — | — | US | disclosed |
| US-8466287-B2 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2013-06-18 | — | — | US | disclosed |
| US-20120041204-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2012-02-16 | — | — | US | disclosed |
| US-20120041204-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2012-02-16 | — | — | US | disclosed |
| US-20120041204-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2012-02-16 | — | — | US | disclosed |
| US-8067595-B2 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2011-11-29 | — | — | US | disclosed |
| US-8067595-B2 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2011-11-29 | — | — | US | disclosed |
| US-8067595-B2 | Process for producing tricyclic ketone | KABUSHIKI KAISHA YAKULT HONSHA (JP) | 2011-11-29 | — | — | US | disclosed |
| EP-1378505-A1 | METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS | Kabushiki Kaisha Yakult Honsha (JP) | 2004-01-07 | — | — | EP | disclosed |
| US-6620937-B2 | Annulation, cyclization | UNIVERSITY OF PITTSBURGH | 2003-09-16 | — | — | US | disclosed |
| US-20030073840-A1 | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-04-17 | — | — | US | disclosed |
| WO-2003018559-A2 | INTERMEDIATES AND PREPARATION THEREOF FOR THE ENANTIOSELECTIVE SYNTHESIS OF (20R) HOMOCAMPTOTHECINS | UNIVERSITY OF PITTSBURGH (US) | 2003-03-06 | — | — | WO | disclosed |
| EP-1269170-A1 | REACTION AND SEPARATION METHODS | UNIVERSITY OF PITTSBURGH (US) | 2003-01-02 | — | — | EP | disclosed |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-10-11 | — | — | US | disclosed |
| WO-2001061332-A1 | REACTION AND SEPARATION METHODS | UNIVERSITY OF PITTSBURGH (US) | 2001-08-23 | — | — | WO | disclosed |
| US-6252079-B1 | CYCLIZATION OF CHEMICAL INTERMEDIATE; REACTING WITH ARYL ISONITRILE | UNIVERSITY OF PITTSBURGH | 2001-06-26 | — | — | US | disclosed |
| US-6211371-B1 | REACTING AN ARYL ISONIRILE WITH AN ISOQUINOLIN-1-ONE COMPOUND | UNIVERSITY OF PITTSBURGH | 2001-04-03 | — | — | US | disclosed |
| WO-1999001456-A1 | SYNTHESIS OF AND INTERMEDIATES FOR CAMPTOTHECINS | UNIVERSITY OF PITTSBURGH (US) | 1999-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073840-A1 | Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins | FOLR1, POR, FOLR2 | MCL1 70/4885ERN1 3713/4885 |
| US-20120041204-A1 | PROCESS FOR PRODUCING TRICYCLIC KETONE | TKT, DCK, COASY | MCL1 1094/4885ERN1 1153/4885 |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | CGAS, APEX1, DHPS | MCL1 326/4885ERN1 1318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.