Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.67 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161326 | 0.89 | GPR119 (0.52) | GPR119CHRM4TGFBR1 | |
| SCHEMBL1458887 | 0.84 | GPR119 (0.76) | GPR119 | |
| SCHEMBL314057 | 0.84 | GPR119 (0.59) | GPR119CHRM4 | |
| SCHEMBL18891231 | 0.82 | KDM4E (0.64) | GPR119CHRM4KDM4EPKM | |
| SCHEMBL314929 | 0.82 | CHRM4 (0.61) | GPR119CHRM4KDM4E | |
| SCHEMBL6156540 | 0.81 | GPR119 (0.53) | GPR119KDM4EPKM | |
| SCHEMBL30980711 | 0.81 | GPR119 (0.70) | GPR119CHRM4KDM4EPKM | |
| Hydrochloric Acid SCHEMBL6150359 | 0.81 | CHRM4 (0.60) | GPR119CHRM4KDM4E | |
| SCHEMBL12736051 | 0.81 | GPR119 (0.59) | GPR119KDM4EPKMTGFBR1 | |
| SCHEMBL3360747 | 0.81 | KDM4E (0.56) | GPR119CHRM4KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143391-A1 | Heterocyclic amides with alpha-4 integrin antagonist activity | J. Uriach Y Compañia S.A. (ES) | 2005-06-30 | — | — | US | disclosed |
| EP-1495044-A1 | HETEROCYCLIC AMIDES WITH ALPHA-4 INTEGRIN ANTAGONIST ACTIVITY | J. Uriach y Compania S.A. (ES) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003084984-A1 | HETEROCYCLIC AMIDES WITH ALPHA-4 INTEGRIN ANTAGONIST ACTIVITY | J. URIACH Y COMPANIA S.A. (ES) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143391-A1 | Heterocyclic amides with alpha-4 integrin antagonist activity | ITGB4, ITGA4, ITGA1 | GPR119 789/4885CHRM4 205/4885KDM4E 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.