Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352872 | 0.90 | ABCG2 (0.41) | POLBSMN1; SMN2L3MBTL1ALOX5ALDH1A1 | |
| SCHEMBL4617609 | 0.85 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2L3MBTL1TSHRMAPK1 | |
| SCHEMBL7348668 | 0.84 | POLB (0.40) | POLBSMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL6187421 | 0.83 | AOC3 (0.47) | POLBSMN1; SMN2L3MBTL1TSHRMAPK1 | |
| SCHEMBL6155 | 0.78 | POLB (0.39) | POLBSMN1; SMN2L3MBTL1TSHRALDH1A1 | |
| SCHEMBL4638150 | 0.76 | AGTR1 (0.45) | POLBSMN1; SMN2ALOX5ALDH1A1CYP2A6 | |
| SCHEMBL7352477 | 0.76 | ABCG2 (0.41) | POLBSMN1; SMN2L3MBTL1TSHRMAPK1 | |
| SCHEMBL7772778 | 0.73 | ABCG2 (0.44) | POLBSMN1; SMN2L3MBTL1TSHRMAPK1 | |
| SCHEMBL6264 | 0.71 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1LMNACYP2A6RAB9A | |
| SCHEMBL4415031 | 0.71 | SMN1; SMN2 (0.60) | POLBSMN1; SMN2L3MBTL1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900210-B1 | ANTIVIRALLY ACTIVE HETEROCYCLIC AZAHEXANE DERIVATIVES | NOVARTIS AG (CH) | 2005-02-09 | — | — | EP | disclosed |
| US-6300519-B1 | REACTING HYDRAZINE DERIVATIVE WITH EPOXIDE COMPOUND | NOVARTIS FINANCE CORPORATION | 2001-10-09 | — | — | US | disclosed |
| US-6166004-A | Combinations of HIV protease inhibitors with reverse transcriptase inhibitors | NOVARTIS FINANCE CORPORATION (US) | 2000-12-26 | — | — | US | disclosed |
| US-6110946-A | AN ENZYME INHIBITORS OF RETROVIRAL ASPARTATE PROTEASE FOR THE TREATMENT OF AIDS | NOVARTIS FINANCE CORPORATION (US) | 2000-08-29 | — | — | US | disclosed |