Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352872 | 0.89 | ABCG2 (0.41) | POLBSMN1; SMN2ABCG2AGTR1XDH | |
| SCHEMBL8784604 | 0.88 | ABCG2 (0.39) | POLBSMN1; SMN2ABCG2KCNJ1AGTR1 | |
| SCHEMBL6156586 | 0.84 | POLB (0.47) | POLBSMN1; SMN2ALDH1A1NPC1MAPT | |
| SCHEMBL6155 | 0.79 | POLB (0.39) | POLBSMN1; SMN2ABCG2AGTR1XDH | |
| SCHEMBL8783660 | 0.79 | SMN1; SMN2 (0.40) | POLBSMN1; SMN2ABCG2AGTR1ALDH1A1 | |
| SCHEMBL4617609 | 0.77 | SMN1; SMN2 (0.56) | POLBSMN1; SMN2ALDH1A1MEN1NPC1 | |
| SCHEMBL4638150 | 0.77 | AGTR1 (0.45) | POLBSMN1; SMN2ABCG2KCNJ1AGTR1 | |
| SCHEMBL7772778 | 0.76 | ABCG2 (0.44) | POLBSMN1; SMN2ABCG2AGTR1ALDH1A1 | |
| SCHEMBL7352477 | 0.76 | ABCG2 (0.41) | POLBSMN1; SMN2ABCG2KCNJ1AGTR1 | |
| SCHEMBL8783257 | 0.74 | TDP1 (0.36) | SMN1; SMN2ABCG2MEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760815-A1 | PROCESSES FOR PREPARING 1-BUTYL-2-[2'-(2H-TETRAZOL-5-YL)-BIPHENYL-4-YLMETHYL]-1H-INDOLE-3-CARBOXYLIC ACID | SYNTEX (U.S.A.) INC. (US) | 1997-03-12 | — | — | EP | disclosed |
| WO-1995032962-A1 | PROCESSES FOR PREPARING 1-BUTYL-2-[2'-(2H-TETRAZOL-5-YL)-BIPHENYL-4-YLMETHYL]-1H-INDOLE-3-CARBOXYLIC ACID | SYNTEX (U.S.A.) INC. (US) | 1995-12-07 | — | — | WO | disclosed |
| US-5412102-A | Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid | SYNTEX (U.S.A.) INC. (US) | 1995-05-02 | — | — | US | disclosed |