SCHEMBL6156643

SCHEMBL6156643

Cc1cc(N)c([N+](=O)[O-])c(C)c1N

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
CYP3A4 P08684 3/20 0.46
TDP1 Q9NUW8 3/20 0.46
TSHR P16473 4/20 0.44
GRIN2D O15399 3/20 0.41
GRIN3B O60391 3/20 0.41
GRIN1 Q05586 3/20 0.41
GRIN2A Q12879 3/20 0.41
GRIN2B Q13224 3/20 0.41
GRIN2C Q14957 3/20 0.41
GRIN3A Q8TCU5 3/20 0.41
MEN1 O00255 2/20 0.40
RECQL P46063 2/20 0.40
KMT2A Q03164 2/20 0.40
MAPT P10636 2/20 0.40
POLB P06746 2/20 0.40
KDM4E B2RXH2 1/20 0.40
USP2 O75604 1/20 0.40
PKM P14618 1/20 0.40
APEX1 P27695 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3606399 0.86 ALDH1A1 (0.43) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL6580997 0.86 ALDH1A1 (0.47) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL10623111 0.84 ALDH1A1 (0.46) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL28506763 0.84 ALDH1A1 (0.46) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL6579395 0.84 ALDH1A1 (0.46) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL27445177 0.82 TSHR (0.47) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL11640027 0.81 ALDH1A1 (0.44) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL3219814 0.80 CYP3A4 (0.46) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL8773007 0.80 ALDH1A1 (0.46) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL10617292 0.78 ALDH1A1 (0.41) ALDH1A1CYP3A4TDP1TSHRGRIN2D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100500663-C N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl) -n-phenylamines as antiproliferative compounds CYCLACEL LTD (GB) 2009-06-17 CN claimed
CN-1617870-A N- (4- (4-methylthiazol-5-yl) pyrimidin-2-yl) -N-anilines as antiproliferative compounds CYCLACEL LTD (GB) 2005-05-18 CN claimed
US-4736067-A DIRECT AND OXIDATION HAIR DYES L'OREAL (FR) 1988-04-05 US claimed
EP-0145513-B1 DERIVATIVES OF DIMETHYL-3-NITRO-4-AMINO-ANILINE, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE DYEING OF KERATIN FIBRES L'OREAL (FR) 1988-03-23 EP claimed
CN-111686110-B Compounds and compositions for modulating EGFR mutant kinase activity 株式会社柳韩洋行 2023-06-16 CN disclosed
EP-3604294-B1 COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR MUTANT KINASE ACTIVITIES YUHAN CORP (KR) 2021-05-05 EP disclosed
CN-100500663-C N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl) -n-phenylamines as antiproliferative compounds CYCLACEL LTD (GB) 2009-06-17 CN disclosed
EP-1581231-A1 ANTI-VIRAL COMPOUNDS Cyclacel Limited (GB) 2005-10-05 EP disclosed
CN-1617870-A N- (4- (4-methylthiazol-5-yl) pyrimidin-2-yl) -N-anilines as antiproliferative compounds CYCLACEL LTD (GB) 2005-05-18 CN disclosed
WO-2004043467-A1 ANTI-VIRAL COMPOUNDS CYCLACEL LIMITED (GB) 2004-05-27 WO disclosed
EP-0635483-B1 Process for preparing nitroaniline derivatives SUMITOMO CHEMICAL CO (JP) 1997-10-22 EP disclosed
US-5529583-A HAIR DYE CLAIROL INCORPORATED (US) 1996-06-25 US disclosed
US-4736067-A DIRECT AND OXIDATION HAIR DYES L'OREAL (FR) 1988-04-05 US disclosed