SCHEMBL6580997

SCHEMBL6580997

Cc1cc(N)c([N+](=O)[O-])c(C)c1[N+](=O)[O-]

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
CYP3A4 P08684 3/20 0.47
TDP1 Q9NUW8 3/20 0.47
TSHR P16473 5/20 0.46
RECQL P46063 1/20 0.41
GRIN2D O15399 2/20 0.39
GRIN3B O60391 2/20 0.39
GRIN1 Q05586 2/20 0.39
GRIN2A Q12879 2/20 0.39
GRIN2B Q13224 2/20 0.39
GRIN2C Q14957 2/20 0.39
GRIN3A Q8TCU5 2/20 0.39
NPC1 O15118 1/20 0.39
LMNA P02545 1/20 0.39
TP53 P04637 1/20 0.39
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39
XBP1 P17861 1/20 0.39
HTT P42858 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6156643 0.86 ALDH1A1 (0.46) ALDH1A1CYP3A4TDP1TSHRRECQL
SCHEMBL6579395 0.86 ALDH1A1 (0.46) ALDH1A1CYP3A4TDP1TSHRRECQL
SCHEMBL4918988 0.84 TDP1 (0.52) ALDH1A1CYP3A4TDP1TSHRGRIN2D
SCHEMBL11640027 0.82 ALDH1A1 (0.44) ALDH1A1CYP3A4TDP1TSHRRECQL
SCHEMBL31711437 0.82 GRIN2D (0.42) ALDH1A1CYP3A4TDP1TSHRRECQL
SCHEMBL28506763 0.82 ALDH1A1 (0.46) ALDH1A1CYP3A4TDP1TSHRRECQL
SCHEMBL3219814 0.82 CYP3A4 (0.46) ALDH1A1CYP3A4TDP1TSHRRECQL
SCHEMBL10617292 0.80 ALDH1A1 (0.41) ALDH1A1CYP3A4TDP1TSHRRECQL
SCHEMBL5849951 0.79 ALDH1A1 (0.47) ALDH1A1CYP3A4TDP1TSHRRECQL
SCHEMBL3606399 0.79 ALDH1A1 (0.43) ALDH1A1CYP3A4TDP1TSHRRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1037887-B1 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY PROCTER & GAMBLE (US) 2004-07-14 EP disclosed
US-6486190-B1 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability THE PROCTER & GAMBLE COMPANY 2002-11-26 US disclosed
CN-1284073-A 5- (2-imidazolinylamino) -benzimidazole derivatives, their preparation and their use as alpha-adrenergic receptor agonists with improved metabolic stability PROCTER & GAMBLE (US) 2001-02-14 CN disclosed
EP-1037887-A1 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY THE PROCTER & GAMBLE COMPANY (US) 2000-09-27 EP disclosed
WO-1999026942-A1 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY THE PROCTER & GAMBLE COMPANY (US) 1999-06-03 WO disclosed
US-4844740-A PITCH AND DINITROANILINE UNION CARBIDE CORPORATION (US) 1989-07-04 US disclosed