Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156643 | 0.86 | ALDH1A1 (0.46) | ALDH1A1TDP1CYP3A4GRIN2DGRIN3B | |
| SCHEMBL6579395 | 0.86 | ALDH1A1 (0.46) | ALDH1A1TDP1CYP3A4GRIN2DGRIN3B | |
| SCHEMBL4918988 | 0.84 | TDP1 (0.52) | ALDH1A1TDP1CYP3A4GRIN2DGRIN3B | |
| SCHEMBL6671674 | 0.84 | CYP1A2 (0.52) | ALDH1A1TDP1CYP3A4RECQLMEN1 | |
| SCHEMBL27445177 | 0.84 | TSHR (0.47) | ALDH1A1TDP1CYP3A4GRIN2DGRIN3B | |
| SCHEMBL9793418 | 0.83 | GRIN2D (0.46) | ALDH1A1TDP1CYP3A4GRIN2DGRIN3B | |
| SCHEMBL14020980 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TDP1CYP3A4GRIN2DGRIN3B | |
| SCHEMBL6580997 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TDP1CYP3A4GRIN2DGRIN3B | |
| SCHEMBL5320639 | 0.78 | KDM4E (0.47) | ALDH1A1TDP1CYP3A4MEN1KMT2A | |
| SCHEMBL3219814 | 0.78 | CYP3A4 (0.46) | ALDH1A1TDP1CYP3A4GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119371419-A | PKMYT1 kinase inhibitors | 杭州邦顺制药有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-103508960-B | Benzheterocyclic derivatives | 江苏先声药业有限公司 | 2017-12-12 | — | — | CN | disclosed |
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
| US-6433184-B1 | HEAT AND CHEMICAL RESISTANCE | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2002-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | ACAT1, ACAT2, LCAT | ALDH1A1 88/4885TDP1 2400/4885CYP3A4 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.