Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 4/20 | 0.43 |
| ▸ | CASP1 | P29466 | 6/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6158897 | 0.84 | MMP9 (0.45) | MMP9SLC15A1CA12MMP1CASP1 | |
| SCHEMBL7428604 | 0.84 | MMP9 (0.45) | MMP9SLC15A1CA12MMP1CASP1 | |
| SCHEMBL7397045 | 0.79 | ECE1 (0.60) | MMP9MMP1CASP1MMP2MMP8 | |
| SCHEMBL27561841 | 0.77 | SLC15A1 (0.46) | MMP9SLC15A1CA12MMP1CASP1 | |
| SCHEMBL7395723 | 0.75 | NPC1 (0.50) | MMP9SLC15A1MMP2MMP8 | |
| SCHEMBL6159923 | 0.75 | USP2 (0.39) | MMP9CA12MMP1CASP1MMP2 | |
| SCHEMBL20827013 | 0.73 | CASP1 (0.55) | CASP1 | |
| SCHEMBL6160245 | 0.73 | MMP9 (0.47) | MMP9SLC15A1CA12MMP1 | |
| SCHEMBL7402537 | 0.72 | ECE1 (0.56) | CA12CASP1CA4 | |
| SCHEMBL27544008 | 0.72 | CASP3 (0.59) | CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1082127-A4 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | disclosed |
| CN-1308542-A | Succinamide inhibitors of interleukin-1 beta converting enzyme | WARNET LAMBERT CO (US) | 2001-08-15 | — | — | CN | disclosed |
| EP-1082127-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999056765-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-11-11 | — | — | WO | disclosed |