SCHEMBL6158425

SCHEMBL6158425

N#CCc1cccc(C(=O)c2ccccc2)c1

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.57
ATM Q13315 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
ALDH1A1 P00352 2/20 0.50
MEN1 O00255 1/20 0.50
MAPT P10636 1/20 0.50
HPGD P15428 1/20 0.50
KMT2A Q03164 1/20 0.50
SRD5A2 P31213 1/20 0.50
ENPP2 Q13822 1/20 0.49
PBRM1 Q86U86 1/20 0.49
CYP19A1 P11511 1/20 0.48
FFAR1 O14842 1/20 0.47
MMP3 P08254 1/20 0.46
VNN1 O95497 2/20 0.46
STS P08842 1/20 0.44
FOLH1 Q04609 1/20 0.43
CNR2 P34972 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11453181 0.87 VNN1 (0.45) L3MBTL1ATMTDP1ALDH1A1MAPT
SCHEMBL2705263 0.86 FOLH1 (0.59) KMT2AENPP2FFAR1MMP3FOLH1
SCHEMBL29471974 0.86 FOLH1 (0.59) KMT2AENPP2FFAR1MMP3FOLH1
SCHEMBL7492979 0.84 KMT2A (0.54) L3MBTL1ATMTDP1ALDH1A1MEN1
SCHEMBL9427483 0.84 CYP19A1 (0.55) TDP1ALDH1A1MEN1MAPTHPGD
SCHEMBL6453539 0.83 KMT2A (0.59) L3MBTL1ATMTDP1ALDH1A1MEN1
SCHEMBL10545624 0.83 L3MBTL1 (0.57) L3MBTL1ATMTDP1ALDH1A1MAPT
SCHEMBL9004062 0.81 MAOB (0.51) MAPTENPP2FFAR1MMP3
SCHEMBL2857119 0.81 ENPP2 (0.50) L3MBTL1TDP1MAPTENPP2FFAR1
SCHEMBL11459736 0.81 ENPP2 (0.50) TDP1ALDH1A1MAPTKMT2AENPP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119912328-A Dexketoprofen ammonia preparation process of butanetriol 山东鲁宁药业有限公司 2025-05-02 CN claimed
EP-1358168-B1 TRICYCLIC LACTAM AND SULTAM DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS HOFFMANN LA ROCHE (CH) 2005-08-10 EP claimed
EP-0525506-B2 A process for the alpha-monoalkylation of arylacetonitriles, arylacetoesters and arylacetic acids TESSENDERLO CHEM NV (BE) 1999-03-17 EP claimed
EP-0525506-A2 A process for the alpha-monoalkylation of arylacetonitriles, arylacetoesters and arylacetic acids TESSENDERLO CHEMIE N.V. (BE) 1993-02-03 EP claimed
US-4230884-A METHYLATION, HYDROLYSIS, WITH CATALYST LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) 1980-10-28 US claimed
US-4201870-A Process for the preparation of 2-(3-benzoylphenyl)-propionic acid LEK TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) 1980-05-06 US claimed
CN-121627502-A Preparation method of ketoprofen 浙江东亚药业股份有限公司 2026-03-10 CN disclosed
CN-119912328-A Dexketoprofen ammonia preparation process of butanetriol 山东鲁宁药业有限公司 2025-05-02 CN disclosed
CN-119912328-A Dexketoprofen ammonia preparation process of butanetriol 山东鲁宁药业有限公司 2025-05-02 CN disclosed
CN-119012727-A Solar cell, preparation method thereof, photovoltaic module, photovoltaic system and electricity utilization device 宁德时代新能源科技股份有限公司 2024-11-22 CN disclosed
CN-116444398-B Preparation method of ketoprofen intermediate formula III 浙江瑞博制药有限公司 2024-06-07 CN disclosed
CN-116554017-A Three-step preparation method of ketoprofen general formula compound 浙江瑞博制药有限公司 2023-08-08 CN disclosed
CN-116444361-A Six-step preparation method of ketoprofen general formula compound 浙江瑞博制药有限公司 2023-07-18 CN disclosed
US-4230884-A METHYLATION, HYDROLYSIS, WITH CATALYST LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) 1980-10-28 US disclosed
US-4230884-A METHYLATION, HYDROLYSIS, WITH CATALYST LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) 1980-10-28 US disclosed
US-4201870-A Process for the preparation of 2-(3-benzoylphenyl)-propionic acid LEK TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) 1980-05-06 US disclosed
US-4201870-A Process for the preparation of 2-(3-benzoylphenyl)-propionic acid LEK TOVARNA FARMACEVTSKIH IN KEMICNIH IZDELKOV, N.SOL.O. (YU) 1980-05-06 US disclosed
US-4192890-A Novel benzoylphenylacetic acid esters ROUSSEL UCLAF (FR) 1980-03-11 US disclosed
US-3995056-A Butyric acid derivatives for treating pain and inflammation ROUSSEL-UCLAF (FR) 1976-11-30 US disclosed
US-3931302-A ANTIINFLAMMATORY, ANALGESIC ROUSSEL-UCLAF (FR) 1976-01-06 US disclosed