SCHEMBL6159935

SCHEMBL6159935

CC(C)(C)C(=O)C(Cl)C(=O)Nc1cccc(N)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.68
HSP90AA1 P07900 2/20 0.68
GPR55 Q9Y2T6 1/20 0.68
ALDH1A1 P00352 3/20 0.55
DDX3X O00571 2/20 0.54
SMN1; SMN2 Q16637 3/20 0.47
LMNA P02545 4/20 0.46
GAA P10253 2/20 0.46
ATM Q13315 2/20 0.46
PTGS1 P23219 3/20 0.46
MAPK13 O15264 1/20 0.44
MAPK12 P53778 1/20 0.44
MAPK11 Q15759 1/20 0.44
MAPK14 Q16539 1/20 0.44
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11382683 0.84 MAPT (0.61) MAPTHSP90AA1GPR55ALDH1A1DDX3X
SCHEMBL11426024 0.81 ALDH1A1 (0.62) MAPTHSP90AA1ALDH1A1DDX3XSMN1; SMN2
SCHEMBL10698727 0.81 MAPT (1.00) MAPTHSP90AA1GPR55ALDH1A1SMN1; SMN2
SCHEMBL11420255 0.81 DDX3X (0.65) MAPTALDH1A1DDX3XSMN1; SMN2LMNA
SCHEMBL9360058 0.80 ALDH1A1 (0.53) MAPTHSP90AA1GPR55ALDH1A1DDX3X
SCHEMBL11380572 0.78 NPC1 (0.60) MAPTHSP90AA1GPR55ALDH1A1SMN1; SMN2
SCHEMBL11693198 0.78 ATM (0.72) MAPTHSP90AA1GPR55ALDH1A1DDX3X
SCHEMBL11094992 0.78 MAPT (0.61) MAPTHSP90AA1GPR55ALDH1A1DDX3X
SCHEMBL520125 0.78 ALDH1A1 (0.66) MAPTALDH1A1DDX3XSMN1; SMN2LMNA
SCHEMBL3209453 0.78 ALDH1A1 (0.66) MAPTALDH1A1DDX3XSMN1; SMN2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0711758-B1 Method of manufacturing a 3-substituted-3-oxo-2-halopropionic acid amide compound and method of manufacturing a 3-substituted-3-oxo-2-(5,5-dimethylhydantoin-3-yl) propionic acid amide compound FUJI PHOTO FILM CO LTD (JP) 2005-01-26 EP disclosed
EP-1020450-B1 3-substituted-3-oxo-2-(5,5-dimethylhydantoin-3-yl) propionic acid amide compound and process for preparation thereof FUJI PHOTO FILM CO LTD (JP) 2004-02-11 EP disclosed
EP-1020450-A1 Method of manufacturing a 3-substituted-3-oxo-2-halopropionic acid amide compound and method of manufacturing a 3-substituted-3-oxo-2-(5,5-dimethylhydantoin-3-yl) propionic acid amide compound FUJI PHOTO FILM CO., LTD. (JP) 2000-07-19 EP disclosed
US-5672714-A HALOGENATION WITH 1,3-DIHALO-5,5-DIMETHYLHYDANTOIN FOLLOWED BY REACTION WITH 5,5-DIMETHYLHYDANTOIN AT THE HALOGENATION SITE TO FORM PHOTOGRAPHIC YELLOW COUPLER COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1997-09-30 US disclosed
EP-0711758-A2 Method of manufacturing a 3-substituted-3-oxo-2-halopropionic acid amide compound and method of manufacturing a 3-substituted-3-oxo-2-(5,5-dimethylhydantoin-3-yl) propionic acid amide compound FUJI PHOTO FILM CO., LTD. (JP) 1996-05-15 EP disclosed
US-4525450-A Silver halide color photographic light sensitive material containing a coupler containing at least one of a sulfamoylphenylenesulfonyl, sulfamoylaminophenylenesulfonyl, or sulfoamidophenylenesulfonyl group FUJI PHOTO FILM CO., LTD. (JP) 1985-06-25 US disclosed
EP-0041170-B1 3-NITRO-PIVALOYL-ACETANILIDES, PROCESSES FOR THEIR PREPARATION AND THEIR UTILIZATION BAYER AG (DE) 1984-07-25 EP disclosed
US-4370499-A CHEMICAL INTERMEDIATES FOR COLOR PHOTOGRAPHY BAYER AKTIENGESELLSCHAFT (DE) 1983-01-25 US disclosed
EP-0017833-B1 COLOUR-PHOTOGRAPHIC RECORDING MATERIAL CONTAINING A YELLOW COUPLER Agfa-Gevaert AG (DE) 1982-01-20 EP disclosed
EP-0041170-A1 3-Nitro-pivaloyl-acetanilides, processes for their preparation and their utilization BAYER AG (DE) 1981-12-09 EP disclosed
US-4289847-A 2-EQUIVALENT YELLOW COUPLER KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1981-09-15 US disclosed
EP-0017833-A1 Colour-photographic recording material containing a yellow coupler Agfa-Gevaert AG (DE) 1980-10-29 EP disclosed
US-4012258-A POLY-FLUORO-ALKYL MAGENTA OR CYAN COUPLER KONISHIROKU PHOTO INDUSTRY CO., LTD. (JA) 1977-03-15 US disclosed