Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.59 |
| ▸ | DRD2 | P14416 | 6/20 | 0.59 |
| ▸ | HTR7 | P34969 | 9/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162906 | 0.82 | HTR1A (0.71) | HTR1ADRD2HTR7CYP2D6HTR2A | |
| SCHEMBL15743195 | 0.81 | MAPT (0.61) | HTR1ADRD2HTR7HTR6HTR2A | |
| SCHEMBL946834 | 0.80 | SIGMAR1 (0.59) | HTR1ADRD2HTR7CYP2D6SIGMAR1 | |
| SCHEMBL3194731 | 0.80 | KDM4E (0.70) | HTR1ADRD2HTR7CYP2D6SIGMAR1 | |
| SCHEMBL3200963 | 0.79 | ADRA1B (0.60) | HTR1ADRD2HTR7CYP2D6SIGMAR1 | |
| SCHEMBL3200107 | 0.79 | ADRA1B (0.60) | HTR1ADRD2HTR7CYP2D6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL3196048 | 0.79 | SIGMAR1 (0.58) | HTR1ADRD2HTR7CYP2D6SIGMAR1 | |
| SCHEMBL7058033 | 0.78 | DRD3 (0.55) | HTR1ADRD2CYP2D6SIGMAR1HTR2A | |
| SCHEMBL3025110 | 0.78 | CYP2D6 (0.90) | HTR1ADRD2HTR7CYP2D6SIGMAR1 | |
| SCHEMBL3196223 | 0.77 | HTR1A (0.57) | HTR1ADRD2HTR7CYP2D6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060163-B1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | KLINGE CO CHEM PHARM FAB (DE) | 2005-10-12 | — | — | EP | disclosed |
| US-6903118-B1 | Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides | KLINGE PHARMA GMBH (DE) | 2005-06-07 | — | — | US | disclosed |
| EP-1060163-A1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | Klinge Pharma GmbH (DE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999031063-A1 | NEW PIPERAZINYL-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |