Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.79 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.68 |
| ▸ | HTR1A | P08908 | 6/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250712 | 0.98 | CYP2D6 (0.87) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL7971932 | 0.98 | CYP2D6 (0.87) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 | |
| SCHEMBL11242236 | 0.98 | CYP2D6 (0.87) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 | |
| SCHEMBL11355026 | 0.98 | CYP2D6 (0.87) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 | |
| SCHEMBL5187793 | 0.95 | CYP2D6 (1.00) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL7986315 | 0.93 | CYP2D6 (0.96) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 | |
| SCHEMBL4528457 | 0.89 | KCNH2 (1.00) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 | |
| SCHEMBL10684565 | 0.87 | CYP2D6 (0.79) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 | |
| SCHEMBL658968 | 0.87 | CYP2D6 (0.79) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 | |
| SCHEMBL5988317 | 0.87 | KCNH2 (0.88) | CYP2D6KCNH2SIGMAR1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029682-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | PIERRE FABRE MEDICAMENT (FR) | 2010-02-04 | — | — | US | claimed |
| EP-1836192-A2 | ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | Universita' Degli Studi di Siena (IT) | 2007-09-26 | — | — | EP | claimed |
| WO-2006072608-A2 | ARYL PIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | UNIVERSITÁ DEGLI STUDI DI SIENA (IT) | 2006-07-13 | — | — | WO | claimed |
| CN-111253325-A | Amino quinazoline aryl piperazine compound and pharmaceutical composition and application thereof | 广州大学 | 2020-06-09 | — | — | CN | disclosed |
| EP-2906221-B1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | SOUTHERN RES INST (US) | 2019-05-15 | — | — | EP | disclosed |
| US-9969743-B2 | Urea and amide derivatives of aminoalkylpiperazines and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170190711-A1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | SOUTHERN RESEARCH INSTITUTE | 2017-07-06 | — | — | US | disclosed |
| US-9598387-B2 | Urea and amide derivatives of aminoalkylpiperazines and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2017-03-21 | — | — | US | disclosed |
| US-20150232435-A1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2015-08-20 | — | — | US | disclosed |
| US-8575185-B2 | Compositions, synthesis, and methods of utilizing quinazolinedione derivatives | REVIVA PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8227604-B2 | Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering CNS activity | WAYNE STATE UNIVERSITY (US) | 2012-07-24 | — | — | US | disclosed |
| WO-2006015737-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2006-02-16 | — | — | WO | disclosed |
| US-20060020132-A1 | Hybrid 2-aminoterailin and aryl-substituted piperazine compounds and their use in altering CNS activity | WAYNE STATE UNIVERSITY (US) | 2006-01-26 | — | — | US | disclosed |
| US-6982332-B2 | Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering CNS activity | WAYNE STATE UNIVERSITY (US) | 2006-01-03 | — | — | US | disclosed |
| US-20030195219-A1 | Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering cns activity | WAYNE STATE UNIVERSITY | 2003-10-16 | — | — | US | disclosed |
| WO-2002098367-A2 | HYBRID 2-AMINOTETRALIN AND ARYL-SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE IN ALTERING CNS ACTIVITY | WAYNE STATE UNIVERSITY (US) | 2002-12-12 | — | — | WO | disclosed |
| CN-1223659-A | Fused imidazopyridine derivatives as antihyperlipidemic agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |
| EP-0000220-B1 | DIHYDROURACILS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-04-29 | — | — | EP | disclosed |
| US-4216216-A | TREATING MIGRAINE HEADACHES, ANTI-HISTAMINES | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-08-05 | — | — | US | disclosed |
| EP-0000220-A1 | Dihydrouracils, process for their preparation and pharmaceuticals containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029682-A1 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME | DRD3, CHRNA3, CHRM3 | CYP2D6 896/4885KCNH2 1015/4885SIGMAR1 109/4885 |
| US-20030195219-A1 | Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering cns activity | HTR3A, HTR3C, HTR2C | CYP2D6 101/4885KCNH2 1208/4885SIGMAR1 341/4885 |
| US-20170190711-A1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | HTR2C, HTR4, HTR2A | CYP2D6 299/4885KCNH2 1099/4885SIGMAR1 47/4885 |
| US-20150232435-A1 | UREA AND AMIDE DERIVATIVES OF AMINOALKYLPIPERAZINES AND USE THEREOF | DRD2, CHRM2, NPY2R | CYP2D6 372/4885KCNH2 1201/4885SIGMAR1 65/4885 |
| US-20060020132-A1 | Hybrid 2-aminoterailin and aryl-substituted piperazine compounds and their use in altering CNS activity | HTR3A, DRD3, DRD2 | CYP2D6 201/4885KCNH2 1371/4885SIGMAR1 328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.