Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.34 |
| ▸ | XIAP | P98170 | 4/20 | 0.34 |
| ▸ | HSD17B13 | Q7Z5P4 | 2/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6158938 | 0.82 | MME (0.43) | MMEACERIPK1XIAPHSD17B13 | |
| SCHEMBL6159420 | 0.78 | XIAP (0.38) | MMEACEXIAP | |
| SCHEMBL7668014 | 0.75 | CCR2 (0.33) | MMEACERIPK1 | |
| SCHEMBL6159304 | 0.73 | MME (0.39) | MMEACERIPK1XIAP | |
| SCHEMBL6158985 | 0.68 | CASP1 (0.46) | MMEACE | |
| SCHEMBL6159042 | 0.66 | KDM4E (0.33) | — | |
| SCHEMBL6158934 | 0.66 | MME (0.44) | MMEACE | |
| SCHEMBL6158994 | 0.66 | SMN1; SMN2 (0.36) | MMEACERIPK1XIAPTAS1R3 | |
| SCHEMBL646016 | 0.63 | CASP1 (0.58) | MMEACE | |
| SCHEMBL6157969 | 0.63 | HSD17B10 (0.37) | RIPK1XIAPTAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062210-B1 | 1,2-DIAZEPANE DERIVATIVES AS INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS | VERTEX PHARMA (US) | 2005-06-01 | — | — | EP | disclosed |
| US-6426413-B1 | SUCH AS (N-BENZYLOXYCARBONYL-HYDRAZINO)-ACETIC ACID TERT-BUTYL ESTER; FOR PREVENTING AND TREATING INTERLEUKIN-MEDIATED DISEASES, APOPTOSIS, AUTOIMMUNE DISEASES, BONE DISORDERS, PROLIFERATIVE DISORDERS, INFECTIONS, AND DEGENERATIVE DISEASES | VERTEX PHARMACEUTICALS INCORPORATED | 2002-07-30 | — | — | US | disclosed |
| EP-1062210-A1 | 1,2-DIAZEPANE DERIVATIVES AS INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046248-A1 | 1,2-DIAZEPANE DERIVATIVES AS INTERLEUKIN-1BETA CONVERTING ENZYME INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1999-09-16 | — | — | WO | disclosed |