Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | TERF2 | Q15554 | 8/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.32 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.32 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159042 | 0.90 | KDM4E (0.33) | CCR2TERF2 | |
| SCHEMBL6158938 | 0.83 | MME (0.43) | MMEACERIPK1 | |
| SCHEMBL7668008 | 0.79 | CASP3 (0.43) | CASP1CASP8CASP3 | |
| SCHEMBL6161334 | 0.75 | MME (0.34) | MMEACERIPK1 | |
| SCHEMBL6159304 | 0.74 | MME (0.39) | MMEACERIPK1 | |
| SCHEMBL6159038 | 0.70 | CASP3 (0.39) | CASP1CASP8CASP3 | |
| SCHEMBL6160332 | 0.69 | CASP1 (0.43) | CASP1CASP8CASP3 | |
| SCHEMBL5903385 | 0.63 | CASP1 (0.55) | CASP1CASP8 | |
| SCHEMBL5903611 | 0.63 | CASP1 (0.49) | CASP1CASP8CASP3RIPK1 | |
| SCHEMBL3269454 | 0.63 | KLK7 (0.53) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6426413-B1 | SUCH AS (N-BENZYLOXYCARBONYL-HYDRAZINO)-ACETIC ACID TERT-BUTYL ESTER; FOR PREVENTING AND TREATING INTERLEUKIN-MEDIATED DISEASES, APOPTOSIS, AUTOIMMUNE DISEASES, BONE DISORDERS, PROLIFERATIVE DISORDERS, INFECTIONS, AND DEGENERATIVE DISEASES | VERTEX PHARMACEUTICALS INCORPORATED | 2002-07-30 | — | — | US | disclosed |