Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499433 | 0.90 | HPGD (0.35) | HPGD | |
| SCHEMBL5499197 | 0.87 | CXCR4 (0.48) | CXCR4SIGMAR1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL7543987 | 0.82 | CXCR4 (0.53) | CXCR4SIGMAR1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL31466474 | 0.79 | POLB (0.43) | CXCR4SIGMAR1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL5622307 | 0.77 | KEAP1 (0.40) | SIGMAR1HPGDPOLBSMN1; SMN2KDM1A | |
| SCHEMBL947587 | 0.70 | CXCR4 (0.50) | CXCR4SIGMAR1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL5498783 | 0.70 | PAOX (0.41) | SIGMAR1HPGDCHRM2CHRM4CHRM5 | |
| SCHEMBL6616866 | 0.69 | GNAO1 (0.41) | CXCR4SIGMAR1 | |
| SCHEMBL5616506 | 0.69 | CXCR4 (0.46) | CXCR4SIGMAR1POLBSMN1; SMN2CHRM2 | |
| SCHEMBL16162069 | 0.69 | CXCR4 (0.46) | CXCR4SIGMAR1POLBSMN1; SMN2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528925-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004004732-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |