Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161463 | 0.90 | CXCR4 (0.39) | HPGD | |
| SCHEMBL5622307 | 0.85 | KEAP1 (0.40) | HPGDALDH1A1 | |
| SCHEMBL5498783 | 0.78 | PAOX (0.41) | HPGDNPC1ALDH1A1 | |
| SCHEMBL643893 | 0.75 | HRH3 (0.48) | CYP1A2ALDH1A1 | |
| SCHEMBL806010 | 0.75 | GNAI3 (0.41) | HPGDKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL7225776 | 0.75 | HRH3 (0.54) | CYP1A2ALDH1A1 | |
| SCHEMBL1097457 | 0.73 | KMT2A (0.37) | HPGDKMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL4526651 | 0.72 | KEAP1 (0.52) | HPGDCYP1A2ALDH1A1 | |
| SCHEMBL5499197 | 0.72 | CXCR4 (0.48) | CYP1A2 | |
| SCHEMBL4057851 | 0.71 | KMT2A (0.40) | HPGDKMT2AMEN1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005470-B1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2007-08-01 | — | — | EP | disclosed |