Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4923120 | 0.99 | CYP11B2 (0.59) | CYP11B2CYP11B1RPS6KB1ROCK1HDAC1 | |
| SCHEMBL29056722 | 0.88 | CYP11B2 (0.54) | CYP11B2CYP11B1HDAC1HDAC8HDAC6 | |
| SCHEMBL28236159 | 0.85 | CYP11B2 (0.63) | CYP11B2CYP11B1RPS6KB1ROCK1HDAC1 | |
| SCHEMBL7587030 | 0.82 | CCR5 (0.54) | CYP11B2RPS6KB1ROCK1FPR2OPRM1 | |
| SCHEMBL13319463 | 0.82 | CYP11B2 (0.50) | CYP11B2RPS6KB1ROCK1PRKACAGSK3B | |
| SCHEMBL29056735 | 0.81 | OPRM1 (0.48) | CYP11B2HDAC1HDAC8HDAC6BRD4 | |
| SCHEMBL6160948 | 0.81 | TP53 (0.58) | CYP11B2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL4379304 | 0.81 | CCR5 (0.53) | CYP11B2RPS6KB1ROCK1FPR2OPRM1 | |
| SCHEMBL9876669 | 0.79 | TP53 (0.46) | CYP11B2RPS6KB1ROCK1BRD4PRKACA | |
| SCHEMBL11791438 | 0.79 | OPRM1 (0.45) | CYP11B2RPS6KB1ROCK1PRKACAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0828754-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038471-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1996035713-A1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER, INC. (US) | 1996-11-14 | — | — | WO | disclosed |