Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28523658 | 0.79 | DUT (0.46) | DUT | |
| SCHEMBL1632352 | 0.78 | DUT (0.45) | DUTPARP1PARP2 | |
| SCHEMBL4024207 | 0.78 | PARP1 (0.46) | DUTPARP1PARP2 | |
| SCHEMBL8865301 | 0.77 | DUT (0.44) | DUTPARP1PARP2 | |
| SCHEMBL28437904 | 0.76 | DUT (0.46) | DUTPARP1PARP2 | |
| SCHEMBL30171833 | 0.75 | BTK (0.32) | BTK | |
| SCHEMBL13849326 | 0.75 | P2RX7 (0.41) | PARP1PARP2BTK | |
| SCHEMBL3536122 | 0.73 | DUT (0.49) | DUTPARP1PARP2 | |
| SCHEMBL27339801 | 0.73 | P2RX7 (0.38) | BTK | |
| SCHEMBL9764243 | 0.72 | DUT (0.40) | DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528925-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Astrazeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004004732-A1 | QUINAZOLINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |