SCHEMBL6162141

SCHEMBL6162141

Clc1cccc[n+]1Cc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.47
CYP2C19 P33261 1/20 0.47
ALDH1A1 P00352 4/20 0.43
SMN1; SMN2 Q16637 4/20 0.43
KDM4E B2RXH2 3/20 0.43
HTT P42858 3/20 0.43
HPGD P15428 2/20 0.43
NPC1 O15118 1/20 0.43
MITF O75030 1/20 0.43
GLA P06280 1/20 0.43
GAA P10253 1/20 0.43
RAB9A P51151 1/20 0.43
ACHE P22303 3/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
BCHE P06276 1/20 0.39
LMNA P02545 4/20 0.37
CHKA P35790 3/20 0.37
TP53 P04637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31130749 1.00 CYP2D6 (0.47) CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E
Bromide SCHEMBL571679 0.98 CYP2D6 (0.46) CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E
Bromide SCHEMBL6697756 0.98 CYP2D6 (0.46) CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E
SCHEMBL10333361 0.86 CYP2D6 (0.39) CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E
SCHEMBL25262661 0.84 KDM4E (0.42) CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E
SCHEMBL25282130 0.80 ACHE (0.49) ALDH1A1SMN1; SMN2KDM4EHTTNPC1
Bromide SCHEMBL11799324 0.78 ALDH1A1 (0.37) CYP2D6CYP2C19ALDH1A1SMN1; SMN2HPGD
Benzene SCHEMBL9542509 0.76 KDM4E (0.42) CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E
SCHEMBL19504336 0.75 MAOA (0.40) KDM4ELMNACHKACHKB
Hydrochloric Acid SCHEMBL11363136 0.74 KDM4E (0.47) CYP2D6CYP2C19ALDH1A1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1254133-B9 INDOL-3-YL DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS MERCK PATENT GMBH (DE) 2005-09-07 EP disclosed
EP-1254133-B1 INDOL-3-YL DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS MERCK PATENT GMBH (DE) 2005-04-20 EP disclosed
EP-1254133-A2 INDOL-3-YL DERIVATIVES MERCK PATENT GmbH (DE) 2002-11-06 EP disclosed
WO-2001058893-A2 INDOL-3-YL DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS MERCK PATENT GMBH (DE) 2001-08-16 WO disclosed