Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7479730 | 0.88 | OPRM1 (0.54) | OPRM1ALDH1A1NPSR1LMNAHSP90AB1 | |
| SCHEMBL6769536 | 0.88 | OPRM1 (0.51) | OPRM1ALDH1A1NPSR1LMNAHSP90AB1 | |
| SCHEMBL6770491 | 0.88 | OPRM1 (0.51) | OPRM1ALDH1A1KMT2ANPSR1LMNA | |
| SCHEMBL6164280 | 0.87 | OPRM1 (0.45) | OPRM1ALDH1A1KMT2ANPSR1LMNA | |
| SCHEMBL6769486 | 0.86 | OPRM1 (0.55) | OPRM1ALDH1A1NPSR1LMNAHSP90AB1 | |
| SCHEMBL1220615 | 0.84 | HSP90AA1 (0.53) | OPRM1ALDH1A1KMT2ANPSR1HSP90AB1 | |
| SCHEMBL6163724 | 0.84 | ALDH1A1 (0.65) | OPRM1ALDH1A1KMT2ANPSR1LMNA | |
| SCHEMBL6164703 | 0.84 | OPRM1 (0.45) | OPRM1ALDH1A1KMT2ANPSR1LMNA | |
| SCHEMBL6168169 | 0.81 | OPRM1 (0.53) | OPRM1ALDH1A1KMT2ANPSR1LMNA | |
| SCHEMBL6165127 | 0.80 | ALDH1A1 (0.43) | OPRM1ALDH1A1KMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-B1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-04-20 | — | — | EP | disclosed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |