Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 11/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771525 | 0.88 | OPRM1 (0.50) | OPRM1ALDH1A1LMNAHSP90AB1GAA | |
| SCHEMBL6770491 | 0.87 | OPRM1 (0.51) | OPRM1ALDH1A1LMNAHSP90AB1GAA | |
| SCHEMBL6770581 | 0.86 | ALDH1A1 (0.62) | OPRM1ALDH1A1LMNAHSP90AB1GAA | |
| SCHEMBL6162256 | 0.86 | OPRM1 (0.50) | OPRM1ALDH1A1LMNAHSP90AB1NPSR1 | |
| SCHEMBL6777174 | 0.84 | OPRM1 (0.58) | OPRM1HSP90AB1TP53CA1CA2 | |
| SCHEMBL6772954 | 0.83 | OPRM1 (0.78) | OPRM1HSP90AB1TP53 | |
| SCHEMBL6769419 | 0.83 | SRC (0.47) | OPRM1ALDH1A1LMNACA1SRC | |
| SCHEMBL6767112 | 0.82 | OPRM1 (0.58) | OPRM1HSP90AB1TP53CA1CA2 | |
| SCHEMBL6771827 | 0.81 | ABCG2 (0.37) | SRC | |
| SCHEMBL6772551 | 0.80 | DHODH (0.37) | ALDH1A1LMNANPSR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |