Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 10/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | QDPR | P09417 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24727966 | 0.82 | HTR2C (0.50) | CD274HTR2CSIGMAR1HTR6HTR2A | |
| Hydrochloric Acid SCHEMBL730625 | 0.81 | HTR2C (0.67) | HTR2CSIGMAR1HTR6HTR2AHTR7 | |
| SCHEMBL532892 | 0.79 | HTR2C (0.66) | HTR2CSIGMAR1HTR6HTR2AHTR7 | |
| SCHEMBL7566975 | 0.79 | HTR2C (0.53) | HTR2CSIGMAR1HTR6HTR2AQDPR | |
| SCHEMBL6162919 | 0.77 | HTR2C (0.47) | HTR2CSIGMAR1HTR6HTR2AHTR7 | |
| SCHEMBL8276239 | 0.73 | HTR6 (0.55) | HTR2CSIGMAR1HTR6HTR2AHTR7 | |
| SCHEMBL3774531 | 0.72 | CCNT1 (0.56) | HTR2CSIGMAR1HTR6QDPRKDM4E | |
| Hydrochloric Acid SCHEMBL3690362 | 0.72 | HTR2C (0.61) | HTR2CSIGMAR1HTR6QDPRKDM4E | |
| SCHEMBL2269949 | 0.72 | HTR2C (0.61) | HTR2CSIGMAR1HTR6QDPRKDM4E | |
| Hydrochloric Acid SCHEMBL29882300 | 0.72 | HTR2C (0.61) | HTR2CSIGMAR1HTR6QDPRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |