Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | QDPR | P09417 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8276239 | 0.88 | HTR6 (0.55) | HTR2CHTR6HTR7HTR2ASIGMAR1 | |
| SCHEMBL6161994 | 0.83 | HTR6 (0.53) | HTR2CHTR6HTR7QDPRSIGMAR1 | |
| Hydrochloric Acid SCHEMBL730625 | 0.81 | HTR2C (0.67) | HTR2CHTR6HTR7HTR2AQDPR | |
| SCHEMBL532892 | 0.79 | HTR2C (0.66) | HTR2CHTR6HTR7HTR2AQDPR | |
| SCHEMBL5542320 | 0.79 | HTR2C (0.49) | HTR2CHTR6HTR2AQDPRSIGMAR1 | |
| SCHEMBL27025891 | 0.78 | HTR2C (0.44) | HTR2CHTR6HTR7QDPRSIGMAR1 | |
| SCHEMBL6162517 | 0.77 | CD274 (0.52) | HTR2CHTR6HTR7HTR2AQDPR | |
| SCHEMBL6589127 | 0.77 | SIGMAR1 (0.50) | HTR2CHTR6HTR7HTR2AQDPR | |
| SCHEMBL27007677 | 0.77 | HTR2C (0.47) | HTR2CQDPRSIGMAR1KHKPDE3B | |
| SCHEMBL28506378 | 0.76 | HTR2C (0.60) | HTR2CHTR6HTR7HTR2AQDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |