SCHEMBL6162575

SCHEMBL6162575

COC(=O)CCSc1c(F)c(F)nc(F)c1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR1 P25024 1/20 0.40
CXCR2 P25025 1/20 0.40
TSHR P16473 3/20 0.39
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA13 Q8N1Q1 1/20 0.36
PTGS1 P23219 1/20 0.36
GSTP1 P09211 1/20 0.36
GSTM2 P28161 1/20 0.36
APP P05067 1/20 0.34
HSD17B10 Q99714 3/20 0.34
ALDH1A1 P00352 2/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34
MAPK1 P28482 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6166121 0.90 MEN1 (0.46) CXCR1CXCR2TSHRKMT2AMEN1
SCHEMBL6161347 0.79 CA12 (0.56) TSHRKMT2ACA12CA1CA2
SCHEMBL11397002 0.68 TSHR (0.40) CXCR1CXCR2TSHRPTGS1GSTP1
SCHEMBL18154877 0.67 KMT2A (0.47) TSHRKMT2AMEN1CA12CA1
SCHEMBL21855915 0.66 CXCR1 (0.42) CXCR1CXCR2KMT2AMEN1PTGS1
SCHEMBL10877599 0.66 TP53 (0.52) KMT2AMEN1ALDH1A1HPGDMAPK1
SCHEMBL15315500 0.66 RAB9A (0.46) CXCR1CXCR2TSHRKMT2AMEN1
SCHEMBL22303096 0.65 CXCR1 (0.41) CXCR1CXCR2KMT2AMEN1PTGS1
SCHEMBL23977089 0.65 MAPT (0.46) CXCR1CXCR2KMT2AMEN1GSTP1
SCHEMBL22303520 0.65 MTNR1A (0.48) CXCR1CXCR2KMT2AGSTP1GSTM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934310-B1 THIO ACID DERIVED MONOCYCLIC N-HETEROCYCLICS AS ANTICOAGULANTS SCHERING AG (DE) 2005-02-09 EP disclosed
US-6221886-B1 Thio acid derived monocyclic N-heterocyclics as anticoagulants BERLEX LABORATORIES, INC. 2001-04-24 US disclosed
US-6166014-A Thio acid derived monocyclic N-heterocyclics as anticoagulants BERLEX LABORATORIES, INC. (US) 2000-12-26 US disclosed
US-6162807-A Thio acid derived monocyclic N-heterocyclics as anticoagulants BERLEX LABORATORIES, INC. (US) 2000-12-19 US disclosed
US-6150382-A ENZYME INHIBITORS OF BLOOD COAGULATION FACTOR XA, A SERINE PROTEASE CLASS OF ENZYMES; E.G., 4-HYDROXY-3-((4-(2-CARBOXY-METHYL)THIO-6-(3-(1-METHYL)-6-(3-(1 -METHYL)IMIDAZOLIN-2-YL)-PHENOXY-3,5-DIFLUOROPYRIDINE AND DERIVATIVES BERLEX LABORATORIES, INC. (US) 2000-11-21 US disclosed
US-6034084-A CARDIOVASCULAR DISORDERS BERLEX LABORATORIES, INC. (US) 2000-03-07 US disclosed
US-6004985-A BLOOD-COAGULATION FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. (US) 1999-12-21 US disclosed
EP-0934310-A1 THIO ACID DERIVED MONOCYCLIC $i(N)-HETEROCYCLICS AS ANTICOAGULANTS SCHERING AKTIENGESELLSCHAFT (DE) 1999-08-11 EP disclosed
WO-1998015547-A1 THIO ACID DERIVED MONOCYCLIC N-HETEROCYCLICS AS ANTICOAGULANTS SCHERING AKTIENGESELLSCHAFT (DE) 1998-04-16 WO disclosed