Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5695680 | 0.83 | TSHR (0.46) | GPR139TSHRKMT2ASLC1A3SLC1A2 | |
| SCHEMBL5695682 | 0.83 | TSHR (0.46) | GPR139TSHRKMT2ASLC1A3SLC1A2 | |
| SCHEMBL6057191 | 0.83 | GPR139 (0.53) | GPR139TSHRKMT2AACEPTPN1 | |
| Ammonia Solution, Strong SCHEMBL7436224 | 0.81 | GPR139 (0.51) | GPR139TSHRKMT2AACEPTPN1 | |
| SCHEMBL5695679 | 0.81 | SLC6A3 (0.47) | GPR139TSHRKMT2ASLC1A3SLC1A2 | |
| SCHEMBL5695683 | 0.81 | SLC6A3 (0.47) | GPR139TSHRKMT2ASLC1A3SLC1A2 | |
| SCHEMBL5695631 | 0.80 | GPR139 (0.50) | GPR139TSHRKMT2AACEPTPN1 | |
| SCHEMBL1356206 | 0.80 | GPR139 (0.50) | GPR139TSHRKMT2AACEPTPN1 | |
| SCHEMBL7897731 | 0.80 | GPR139 (0.50) | GPR139TSHRKMT2AACEPTPN1 | |
| SCHEMBL6169492 | 0.79 | CYP1A2 (0.61) | SLC1A3SLC1A2CYP1A2CPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0877740-B1 | THIOL DERIVATIVES WITH METALLOPEPTIDASE INHIBITORY ACTIVITY | ZAMBON SPA (IT) | 2005-03-30 | — | — | EP | disclosed |
| US-5994539-A | Mercapto acyl aminoacid derivatives endowed with dual ACE-NEP inhibitory activity, useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.P.A. (IT) | 1999-11-30 | — | — | US | disclosed |
| US-5760241-A | ANGIOTENSIN CONVERTING ENZYME AND ENKEPHALINASE INHIBITORS; CARDIOVASCULAR DISORDERS | ZAMBON GROUP S.P.A. (IT) | 1998-06-02 | — | — | US | disclosed |