SCHEMBL5695683

SCHEMBL5695683

CCC[C@H](CSC(=O)c1ccccc1)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 2/20 0.47
HDAC1 Q13547 2/20 0.47
HDAC2 Q92769 2/20 0.47
CHRM1 P11229 1/20 0.47
AKR1A1 P14550 1/20 0.47
CHRM3 P20309 1/20 0.47
HTR2A P28223 1/20 0.47
HTR2C P28335 1/20 0.47
ADRA1A P35348 1/20 0.47
HRH1 P35367 1/20 0.47
DRD3 P35462 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
TSHR P16473 1/20 0.43
GPR139 Q6DWJ6 1/20 0.42
KMT2A Q03164 4/20 0.42
SLC6A2 P23975 1/20 0.40
ACE P12821 1/20 0.39
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
GRIK1 P39086 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5695679 1.00 SLC6A3 (0.47) SLC6A3HDAC1HDAC2CHRM1AKR1A1
SCHEMBL5695682 0.87 TSHR (0.46) HDAC1HDAC2TSHRGPR139KMT2A
SCHEMBL5695680 0.87 TSHR (0.46) HDAC1HDAC2TSHRGPR139KMT2A
SCHEMBL9814713 0.84 CPA3 (0.54) TSHRGPR139CYP1A2ALDH1A1
SCHEMBL6576344 0.83 CYP1A2 (0.44) TSHRKMT2AGRIK1CYP1A2MEN1
SCHEMBL6576342 0.83 CYP1A2 (0.44) TSHRKMT2AGRIK1CYP1A2MEN1
SCHEMBL6162834 0.81 GPR139 (0.46) TSHRGPR139KMT2AACESLC1A3
SCHEMBL10647041 0.79 TSHR (0.68) TDP1TSHRGPR139KMT2ACES1
SCHEMBL6209557 0.79 CYP1A2 (0.61) SLC1A3SLC1A2SLC1A1CYP1A2MME
SCHEMBL6169492 0.79 CYP1A2 (0.61) SLC1A3SLC1A2SLC1A1CYP1A2MME

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0947502-B1 NOVEL SULFUR-CONTAINING AMINO ACID DERIVATIVES SANTEN PHARMACEUTICAL CO LTD (JP) 2006-06-21 EP disclosed
EP-0870762-B1 NOVEL AMINO ACID DERIVATIVES HAVING N,N-DIALKYLAMINOPHENYL GROUP SANTEN PHARMACEUTICAL CO LTD (JP) 2004-04-28 EP disclosed
US-6046235-A SULFUR-CONTAINING AMINO ACID DERIVATIVES WHICH HAVE INHIBITORY EFFECTS ON LEUKOTRIENE A4 HYDROLASE AND USEFUL AS THERAPEUTICAL AGENTS FOR INFLAMMATORY DISEASES SUCH AS RHEUMATISM, PSORIASIS, GOUT, CYSTIC FIBROSIS AND BOWL DISEASES SANTEN PHARMACEUTICAL CO., LTD. (JP) 2000-04-04 US disclosed
EP-0947502-A1 NOVEL SULFUR-CONTAINING AMINO ACID DERIVATIVES SANTEN PHARMACEUTICAL CO., LTD. (JP) 1999-10-06 EP disclosed
US-5872281-A COMPOUNDS FOR TREATMENT OF RHEUMATIC DISEASES, PSORIASIS, INTESTINAL INFLAMATION SANTEN PHARMACEUTICAL CO., LTD. (JP) 1999-02-16 US disclosed
EP-0870762-A1 NOVEL AMINO ACID DERIVATIVES HAVING N,N-DIALKYLAMINOPHENYL GROUP SANTEN PHARMACEUTICAL CO., LTD. (JP) 1998-10-14 EP disclosed