Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CCR1 | P32246 | 3/20 | 0.41 |
| ▸ | CCR8 | P51685 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3896844 | 0.84 | NR4A2 (0.43) | LMNAHSP90AA1KDM4EMAPTCCR1 | |
| SCHEMBL144184 | 0.76 | METAP2 (0.48) | LMNAHSP90AA1KDM4EMAPTCCR1 | |
| SCHEMBL6312154 | 0.76 | KDM4E (0.38) | LMNAHSP90AA1KDM4EMAPTCCR1 | |
| SCHEMBL8391499 | 0.76 | MAPT (0.42) | LMNAHSP90AA1KDM4EMAPTCCR1 | |
| SCHEMBL789544 | 0.76 | PSMD14 (0.43) | LMNAHSP90AA1KDM4EMAPTCCR1 | |
| SCHEMBL20264913 | 0.76 | KDM4E (0.39) | LMNAHSP90AA1KDM4EMAPTCCR1 | |
| SCHEMBL2409957 | 0.72 | CCR1 (0.37) | LMNAHSP90AA1KDM4EMAPTCCR1 | |
| SCHEMBL22121642 | 0.72 | LRRK2 (0.38) | LMNAHSP90AA1KDM4EMAPTCCR1 | |
| SCHEMBL1098748 | 0.72 | PDE10A (0.41) | LMNAHSP90AA1KDM4ESMN1; SMN2TSHR | |
| SCHEMBL20265329 | 0.72 | LMNA (0.33) | LMNAHSP90AA1KDM4EMAPTCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024068976-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2024-04-04 | — | — | WO | claimed |
| EP-4345101-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2024-04-03 | — | — | EP | claimed |
| EP-1224165-B1 | NOVEL COMPOUNDS | NEW PHARMA RES SWEDEN AB (SE) | 2005-12-14 | — | — | EP | claimed |
| US-6875764-B1 | Urea and thiourea compounds useful for treatment of coccidiosis | NEW PHARMA RESEARCH SWEDEN AB (SE) | 2005-04-05 | — | — | US | claimed |
| WO-2001030749-B1 | NOVEL COMPOUNDS | NEW PHARMA RES SWEDEN AB (SE) | 2001-06-07 | — | — | WO | claimed |
| WO-2024068976-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2024-04-04 | — | — | WO | disclosed |
| EP-4345101-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2024-04-03 | — | — | EP | disclosed |
| EP-1224165-B1 | NOVEL COMPOUNDS | NEW PHARMA RES SWEDEN AB (SE) | 2005-12-14 | — | — | EP | disclosed |