Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.48 |
| ▸ | METAP1 | P53582 | 2/20 | 0.48 |
| ▸ | COMT | P21964 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8467497 | 0.84 | METAP2 (0.48) | METAP2METAP1COMTCHRM1MMP2 | |
| SCHEMBL6163578 | 0.76 | LMNA (0.41) | METAP2METAP1COMTCHRM1MMP2 | |
| SCHEMBL20264913 | 0.76 | KDM4E (0.39) | METAP2METAP1COMTCHRM1MMP2 | |
| SCHEMBL8391499 | 0.76 | MAPT (0.42) | MMP2TSHRHTTSLC6A2KDM4E | |
| SCHEMBL789544 | 0.76 | PSMD14 (0.43) | MMP2TSHRADRA1AHTTSLC6A2 | |
| SCHEMBL6312154 | 0.76 | KDM4E (0.38) | METAP2METAP1COMTCHRM1MMP2 | |
| SCHEMBL9172751 | 0.75 | MMP2 (0.49) | METAP2METAP1COMTCHRM1MMP2 | |
| SCHEMBL2409957 | 0.72 | CCR1 (0.37) | METAP2METAP1COMTCHRM1MMP2 | |
| SCHEMBL22121642 | 0.72 | LRRK2 (0.38) | MMP2TSHRHTTKDM4EHSP90AA1 | |
| SCHEMBL20265329 | 0.72 | LMNA (0.33) | MMP2TSHRHTTKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101641332-B | Aminated hydroxyquinoline derivatives for the treatment of cancer | BIOPHARMED | 2014-03-12 | — | — | CN | claimed |
| US-8058442-B2 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2011-11-15 | — | — | US | claimed |
| JP-4757024-B2 | — | — | 2011-08-24 | — | — | JP | claimed |
| US-20060234927-A1 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2006-10-19 | — | — | US | claimed |
| EP-1565185-A2 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2005-08-24 | — | — | EP | claimed |
| EP-1465882-A4 | HETROCYCLIC MODULATORS OF NUCLEAR RECEPTORS | X CEPTOR THERAPEUTICS INC (US) | 2005-04-06 | — | — | EP | claimed |
| EP-1465882-A2 | HETROCYCLIC MODULATORS OF NUCLEAR RECEPTORS | X-Ceptor Therapeutics, Inc. (US) | 2004-10-13 | — | — | EP | claimed |
| WO-2004041151-A2 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2004-05-21 | — | — | WO | claimed |
| US-6696473-B2 | THIAZOLIDINONE DERIVATIVES; MODULATING CHOLESTEROL METABOLISM | X-CEPTOR THERAPEUTICS, INC. | 2004-02-24 | — | — | US | claimed |
| WO-2003060078-A9 | HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS | X CEPTOR THERAPEUTICS INC (US) | 2004-02-19 | — | — | WO | claimed |
| US-20030212111-A1 | Heterocyclic modulators of nuclear receptors | AKARNA THERAPEUTICS, LTD. (GB) | 2003-11-13 | — | — | US | claimed |
| WO-2003060078-A2 | HETEROCYCLIC MODULATORS OF NUCLEAR RECEPTORS | X-CEPTOR THERAPEUTICS, INC. (US) | 2003-07-24 | — | — | WO | claimed |
| EP-1189606-A2 | NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | YEDA RESEARCH AND DEVELOPMENT Co. LTD. (IL) | 2002-03-27 | — | — | EP | claimed |
| WO-2000074664-A2 | NOVEL IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING IRON CHELATORS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2000-12-14 | — | — | WO | claimed |
| CN-101641332-B | Aminated hydroxyquinoline derivatives for the treatment of cancer | BIOPHARMED | 2014-03-12 | — | — | CN | disclosed |
| US-20120058945-A1 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) | 2012-03-08 | — | — | US | disclosed |
| US-8058442-B2 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2011-11-15 | — | — | US | disclosed |
| US-4886733-A | Photographic products and processes | POLAROID CORPORATION (US) | 1989-12-12 | — | — | US | disclosed |
| US-3929797-A | Photographic processes and products employing 8-quinolinol phthaleins as optical filter agents | POLAROID CORP | 1975-12-30 | — | — | US | disclosed |
| US-3816123-A | PHOTOGRAPHIC PROCESSES AND PRODUCTS EMPLOYING 8-QUINOLINOL PHTHALEINS AS OPTICAL FILTER AGENTS | POLAROID CORP | 1974-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058945-A1 | NEUROPROTECTIVE IRON CHELATORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | FECH, HMOX1, FTH1 | METAP2 3021/4885METAP1 1862/4885COMT 1313/4885 |
| US-20060234927-A1 | Neuroprotective iron chelators and pharmaceutical compositions comprising them | FECH, HMOX1, FTH1 | METAP2 3014/4885METAP1 1831/4885COMT 1071/4885 |
| US-20030212111-A1 | Heterocyclic modulators of nuclear receptors | NR1H2, NR1H3, NR1H4 | METAP2 4242/4885METAP1 4271/4885COMT 4649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.