Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360691 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2CYP2C19RAB9AGAAL3MBTL1 | |
| SCHEMBL3135799 | 0.78 | LSS (0.41) | LMNABCHE | |
| SCHEMBL4086562 | 0.77 | LSS (0.45) | F2PRSS1BCHE | |
| SCHEMBL27463118 | 0.76 | LMNA (0.48) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL6164881 | 0.75 | LTA4H (0.49) | HTT | |
| SCHEMBL4086461 | 0.74 | ADRB2 (0.41) | SMN1; SMN2LMNAGAAF2PRSS1 | |
| SCHEMBL4422938 | 0.73 | NPC1 (0.53) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL6161203 | 0.72 | MAPK1 (0.40) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL7977833 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2C19NPC1RAB9AGAA | |
| SCHEMBL7975223 | 0.72 | HPGD (0.47) | SMN1; SMN2CAPN1GAAF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134213-B1 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1134213-A2 | Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides | PFIZER INC. (US) | 2001-09-19 | — | — | EP | disclosed |