Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360691 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2CYP2C19ALDH1A1RAB9ATDP1 | |
| SCHEMBL6163787 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP2C19ALDH1A1RAB9AGAA | |
| SCHEMBL27463118 | 0.72 | LMNA (0.48) | SMN1; SMN2ALDH1A1RAB9AKDM4EKMT2A | |
| SCHEMBL6164881 | 0.71 | LTA4H (0.49) | KMT2AHTT | |
| SCHEMBL3138570 | 0.69 | SPHK1 (0.50) | RAB9ANPC1 | |
| SCHEMBL4086816 | 0.69 | TACR1 (0.44) | SMN1; SMN2CYP2C19ALDH1A1GAA | |
| SCHEMBL6163270 | 0.69 | SPHK1 (0.47) | ALDH1A1RAB9ANPC1 | |
| SCHEMBL4095230 | 0.69 | TACR1 (0.44) | SMN1; SMN2CYP2C19ALDH1A1GAA | |
| SCHEMBL6052746 | 0.69 | TACR1 (0.44) | SMN1; SMN2CYP2C19ALDH1A1GAA | |
| SCHEMBL4422938 | 0.68 | NPC1 (0.53) | SMN1; SMN2ALDH1A1RAB9ATDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277877-B1 | GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS | PFIZER, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6107329-A | HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS | PFIZER, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |