SCHEMBL6164944

SCHEMBL6164944

Cc1nn(-c2ccccn2)c2c1C(=O)CC(C)C2

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNA2 P20248 9/20 0.62
CDK2 P24941 9/20 0.62
ALDH1A1 P00352 6/20 0.58
MAPT P10636 5/20 0.58
SMN1; SMN2 Q16637 4/20 0.58
THRB P10828 2/20 0.58
TDP1 Q9NUW8 1/20 0.58
CCNO P22674 1/20 0.52
CCNE1 P24864 1/20 0.52
CCNA1 P78396 1/20 0.52
KDM4E B2RXH2 5/20 0.46
HPGD P15428 4/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
TP53 P04637 1/20 0.46
HTT P42858 1/20 0.46
HSD17B10 Q99714 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
CSNK2A2 P19784 1/20 0.43
CSNK2B P67870 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6164726 0.84 CCNA2 (0.47) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2
SCHEMBL6163369 0.84 CCNA2 (0.47) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2
SCHEMBL6166612 0.84 CCNA2 (0.47) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2
SCHEMBL6164885 0.84 ALDH1A1 (0.58) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2
SCHEMBL6165013 0.82 CCNA2 (0.46) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2
SCHEMBL6167870 0.81 ALDH1A1 (0.49) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2
SCHEMBL6165077 0.81 CCNA2 (0.45) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2
SCHEMBL6167242 0.80 ALDH1A1 (0.62) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2
SCHEMBL6162861 0.77 OPRM1 (0.65) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2
SCHEMBL6166197 0.76 CCNA2 (0.41) CCNA2CDK2ALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1177185-B1 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-04-20 EP disclosed
US-6716856-B1 CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY PHARMACIA & TUBJOHN SPA (IT) 2004-04-06 US disclosed